Caspase 10 antibody (Middle Region)

Catalog No. ABIN929111

The Rabbit Polyclonal anti-Caspase 10 antibody is suitable to detect Caspase 10 in samples from Human. It has been validated for WB.

Quick Overview for Caspase 10 antibody (Middle Region) (ABIN929111)

Target: Caspase 10 (CASP10) (Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase 10 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Caspase 10 Antibody

Binding Specificity: Middle Region

Purification: Purified

Immunogen: CASP10 antibody was raised in rabbit using the middle region of CASP10 as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for Caspase 10

Target: Caspase 10 (CASP10) (Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10))

Alternative Name: CASP10

Background: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene. Synonyms: Polyclonal CASP10 antibody, Anti-CASP10 antibody, caspase 10, apoptosis-related cysteine peptidase antibody, ALPS2 antibody, FLICE2 antibody, MCH4 antibody.

Pathways: Apoptosis, Caspase Cascade in Apoptosis