Caspase 10 antibody (AA 430-479)

Catalog No. ABIN1533218

This Rabbit Polyclonal antibody specifically detects Caspase 10 in WB, ELISA, IHC and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Caspase 10 antibody (AA 430-479) (ABIN1533218)

Target: Caspase 10 (CASP10) (Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase 10 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-Caspase 10 Antibody

Binding Specificity: AA 430-479

Purpose: Caspase-10 B/D Antibody

Specificity: Caspase-10 B/D Polyclonal Antibody detects endogenous levels of proCaspase-10 B/D protein, actived Caspase-10 (isoform B and D) and Caspase-10(isoform B and D) subunit p12,

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human Caspase 10. AA range:430-479

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Caspase 10

Target: Caspase 10 (CASP10) (Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10))

Alternative Name: Caspase 10

Background:

Synonyms: ALPS2, apoptotic protease Mch-4, CASP-10, CASPA, caspase-10, FADD-like ICE2, FAS-associated death domain protein interleukin-1B-convert

Background: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011],

Gene Name: CASP10

Protein Name: Caspase10

Molecular Weight: 58 kDa

Gene ID: 843, 4

OMIM: 601762

UniProt: Q92851-2

Pathways: Apoptosis, Caspase Cascade in Apoptosis