Adenylosuccinate Lyase antibody (Middle Region)

Catalog No. ABIN929409

The Rabbit Polyclonal anti-Adenylosuccinate Lyase antibody (ABIN929409) specifically detects Adenylosuccinate Lyase in WB. The antibody is reactive with Human samples.

Quick Overview for Adenylosuccinate Lyase antibody (Middle Region) (ABIN929409)

Target: Adenylosuccinate Lyase (ADSL)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Adenylosuccinate Lyase antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Adenylosuccinate Lyase Antibody

Binding Specificity: Middle Region

Purification: Purified

Immunogen: ADSL antibody was raised in rabbit using the middle region of ADSL as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

ADSL Blocking Peptide, (ABIN5611964), is also available for use as a blocking control in assays to test for specificity of this ADSL antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for Adenylosuccinate Lyase

Target: Adenylosuccinate Lyase (ADSL)

Alternative Name: ADSL

Background: Adenylsuccinate lyase is involved in both de novo synthesis of purines and formation of adenosine monophosphate from inosine monophosphate. It catalyzes two reactions in AMP biosynthesis: the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and removal of fumarate from adenylosuccinate to give AMP. Adenylosuccinase deficiency results in succinylpurinemic autism, psychomotor retardation, and , in some cases, growth retardation associated with muscle wasting and epilepsy. Two transcript variants encoding different isoforms have been found for this gene. Synonyms: Polyclonal ADSL antibody, Anti-ADSL antibody, adenylosuccinate lyase antibody, AMPS antibody, ASASE antibody, ASL antibody.

Pathways: Ribonucleoside Biosynthetic Process