Adenylosuccinate Lyase antibody (AA 1-310)

Catalog No. ABIN6136602

Product Details anti-Adenylosuccinate Lyase Antibody

Target: Adenylosuccinate Lyase (ADSL)

Binding Specificity: AA 1-310

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Adenylosuccinate Lyase antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Sequence: MAAGGDHGSP DSYRSPLASR YASPEMCFVF SDRYKFRTWR QLWLWLAEAE QTLGLPITDE QIQEMKSNLE NIDFKMAAEE EKRLRHDVMA HVHTFGHCCP KAAGIIHLGA TSCYVGDNTD LIILRNALDL LLPKLARVIS RLADFAKERA SLPTLGFTHF QPAQLTTVGK RCCLWIQDLC MDLQNLKRVR DDLRFRGVKG TTGTQASFLQ LFEGDDHKVE QLDKMVTEKA GFKRAFIITG QTYTRKVDIE VLSVLASLGA SVHKICTDIR LLANLKEMEE PFEKQQIGSS AMPYKRNPMR SERCCSLARH

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human ADSL (NP_000017.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:20 - 1:100,IP,1:50 - 1:100

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Adenylosuccinate Lyase

Target: Adenylosuccinate Lyase (ADSL)

Alternative Name: ADSL (ADSL Products)

Synonyms: fi60b04 antibody, zgc:56061 antibody, wu:fi60b04 antibody, MGC53383 antibody, MGC69239 antibody, adsL antibody, F15C21.8 antibody, F15C21_8 antibody, AMPS antibody, ASASE antibody, ASL antibody, Adl antibody, Asl antibody, purB antibody, adenylosuccinate lyase antibody, adenylosuccinate lyase L homeolog antibody, adenylosuccinase; ASL antibody, Adenylosuccinate lyase antibody, L-Aspartase-like family protein antibody, ADSL antibody, adsl antibody, adsl.L antibody, ASL antibody, purB antibody, purB,adsL antibody, Mrub_2293 antibody, MMAH_RS02975 antibody, Arnit_0089 antibody, Mesil_1058 antibody, Slip_0597 antibody, Trad_2452 antibody, Deba_0652 antibody, Toce_1174 antibody, Acear_2324 antibody, Igag_0272 antibody, Saut_2156 antibody, Fbal_1996 antibody, Ndas_2434 antibody, Ilyop_0196 antibody, Lbys_2961 antibody, MFER_RS02920 antibody, Palpr_2192 antibody, Calni_0061 antibody, Ftrac_3746 antibody, AT1G36280 antibody, Olsu_1764 antibody, Adsl antibody

Background: The protein encoded by this gene belongs to the lyase 1 family. It is an essential enzyme involved in purine metabolism, and catalyzes two non-sequential reactions in the de novo purine biosynthetic pathway: the conversion of succinylaminoimidazole carboxamide ribotide (SAICAR) to aminoimidazole carboxamide ribotide (AICAR) and the conversion of adenylosuccinate (S-AMP) to adenosine monophosphate (AMP). Mutations in this gene are associated with adenylosuccinase deficiency (ADSLD), a disorder marked with psychomotor retardation, epilepsy or autistic features. Alternatively spliced transcript variants have been found for this gene.,ADSL,AMPS,ASASE,ASL,Signal Transduction,Endocrine & Metabolism,ADSL

Molecular Weight: 48 kDa/54 kDa

Gene ID: 158

UniProt: P30566

Pathways: Ribonucleoside Biosynthetic Process