SORL1 antibody (AA 2159-2214)

Catalog No. ABIN931367

The Mouse Monoclonal anti-SORL1 antibody is suitable to detect SORL1 in samples from Human. It has been validated for ELISA and WB.

Quick Overview for SORL1 antibody (AA 2159-2214) (ABIN931367)

Target: SORL1 (Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SORL1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Clone: 7D7B11

Product Details anti-SORL1 Antibody

Binding Specificity: AA 2159-2214

Immunogen: SORL1 antibody was raised in Mouse using a purified recombinant fragment of SORL1(aa2159-2214) expressed in E. coli as the immunogen.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10,000, WB: 1:500-1:2000
Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Supplied as a liquid in ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term storage. Store at -20 °C for long term storage.

Target Details for SORL1

Target: SORL1 (Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1))

Alternative Name: SORL1

Background: SORL1 is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL and transports it into cells by endocytosis. SorLA is synthesized as a proreceptor which is processed to the mature form by a furin-like propeptidase. It can also bind to RAP (receptor-associated protein). SorLA is a multifunctional endocytis receptor important in lipoprotein and protease uptake. The N-terminal propeptide, which is removed, can be cleaved by furin or homologous proteases. Endogenous SorLA binds the neuropeptide head activator (HA) and is important for HA signaling and function. Synonyms: Monoclonal SORL1 antibody, Anti-SORL1 antibody, Sortilin related receptor L A repeats containing antibody.

Pathways: Smooth Muscle Cell Migration