Synaptophysin antibody

Catalog No. ABIN933169

This Mouse Monoclonal antibody specifically detects Synaptophysin in WB and ELISA. It exhibits reactivity toward Human and Rat.

Quick Overview for Synaptophysin antibody (ABIN933169)

Target: Synaptophysin (SYP)

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Synaptophysin antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 7H12

Product Details anti-Synaptophysin Antibody

Cross-Reactivity: Rat (Rattus)

Immunogen: SYP antibody was raised in Mouse using a purified recombinant fragment of SYP expressed in E. coli as the immunogen.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10,000, WB: 1:500-1:2000
Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Supplied as a liquid in ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term storage. Store at -20 °C for long term storage.

Target Details for Synaptophysin

Target: Synaptophysin (SYP)

Alternative Name: SYP

Background: Synaptophysin is an integral membrane protein of small synaptic vesicles in brain and endocrine cells. Synaptophysin contains four transmembrane domains that form a hexameric channel or gap junction-like pore. Synaptophysin binds to the SNARE protein synaptobrevin/VAMP, which prevents the inclusion of synaptobrevin in the synaptic vesicle fusion complex and creates a pool of synaptobrevin for exocytosis when synapse activity increases. Synaptophysin is also responsible for targeting synaptobrevin 2/VAMP2 to synaptic vesicles, a critical component of the fusion complex. Synonyms: Monoclonal SYP antibody, Anti-SYP antibody, Synaptophysin antibody, p38 antibody.

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of long-term Neuronal Synaptic Plasticity