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Antibodies
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anti-Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A) antibody
Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A) antibody
| Antigen |
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| Synonyms |
CD16, FCG3, CD16A, FCGR3, IGFR3, FCR-10, FCRIII, FCGRIII, FCRIIIA |
| Clonality |
Monoclonal (MEM-168) |
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Host
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Reactivity
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Application
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Flow Cytometry (FACS) (117), Immunoprecipitation (IP) (30), Immunohistochemistry (Frozen Sections) (IHC (fro)) (13), Functional Studies (Func) (12), Western Blotting (WB) (12), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (6), Immunocytochemistry (ICC) (5), ELISA (3), ELISA (Detection) (2), Enzyme Immunoassay (EIA) (2), Immunofluorescence (IF) (2), Blocking Antibody (Inhibition) (1), Immunohistochemistry (IHC) (1)
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| Catalog no. |
ABIN93997 |
| Quantity |
0.1 mg (1 mg/ml) |
| Price |
260.00 $ Plus shipping costs $35.00
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| Shipping to |
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| Availability |
Ships within 3 to 5 Business Days |
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Alternative name
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CD16
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Immunogen
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Human granulocytes
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Format
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Purified
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Isotype
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IgM
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Clone
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MEM-168
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Description
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CD16 (FcgammaRIII) is a 50-65 kDa glycoprotein serving as a low affinity IgG receptor.Human FcgammaRIII is expressed in two forms FcgammaRIII-A and -B. FcgammaRIII-A isa transmembrane protein of monocytes, macrophages, NK cells and a subset of T cells. It isassociated with FcepsilonRI-gamma subunit and is responsible for antibody-dependent NKcell cytotoxicity. Mast cell FcgammaRIII-A is associated, moreover, with FcepsilonRI-betasubunit. Besides IgG, FcgammaRIII-A can be triggered also by oligomeric IgE.FcgammaRIII-B is a GPI-linked monomeric receptor expressed on neutrophils and isinvolved in their activation and induction of a proadhesive phenotype.
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Specificity
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The antibody MEM-168 reacts with CD16 antigen, a low affinity receptor for aggregated IgG(FcgammaRIII antigen). CD16 exists in two different isoforms: CD16a (FcgammaRIIIA,50-65 kDa, expressed on NK-cells, monocytes and macrophages) and CD16b(FcgammaRIIIB, 48 kDa, mainly expressed on neutrophils).
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Concentration
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1 mg/ml
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Purity
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> 95% (by SDS-PAGE)
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Purification
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Purified from ascites by gel filtration and precipitation methods.
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Buffer
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Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
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Storage
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Store at 2-8 o C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20 o C. Avoid freeze/thaw cycles.
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Research Area
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Stem Cells, Hematopoietic Progenitors, Hematopoietic Stem Cells, CD Antigens, Surface Receptors of Immune Cells
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Restrictions
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For Research Use only
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Publications
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Drbal, Moertelmaier, Holzhauser et al.: "Single-molecule microscopy reveals heterogeneous dynamics of lipid raft components upon TCR engagement." in: International immunology, Vol. 19, Issue 5, pp. 675-84, 2007 (PubMed).
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Alternatives for antigen "Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A)", type "Antibodies"
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Hosts
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Mouse (120), Rat (6), Rabbit (1)
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Reactivities
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Human (112), Pig (Porcine) (9), Primates (8), Mouse (Murine) (3), Monkey (2), Primate (1)
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Applications
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Flow Cytometry (FACS) (117), Immunoprecipitation (IP) (30), Immunohistochemistry (Frozen Sections) (IHC (fro)) (13), Functional Studies (Func) (12), Western Blotting (WB) (12), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (6), Immunocytochemistry (ICC) (5), ELISA (3), ELISA (Detection) (2), Enzyme Immunoassay (EIA) (2), Immunofluorescence (IF) (2), Blocking Antibody (Inhibition) (1), Immunohistochemistry (IHC) (1)
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Conjugates
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FITC (17), Biotin (14), PE (14), RPE (4), Alexa Fluor 700 (2), Cy5.5,PE (2), SPRD (2), Alexa Fluor 488 (1), PE,Cy5 (1), PE-Dyomics 647 (1), Pacific Blue (1), PerCP (1), RPE,Cy5 (1)
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Alternatives 
