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Details for Product No. ABIN94191

Neural Cell Adhesion Molecule 1 (NCAM1) antibody (APC)

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Antigen
Synonyms CD56, NCAM, MSK39, E-NCAM, NCAM-1, Ncam, Cd56, N-CAM, N-CAM-1, NCAM-C, NCAMC, fj56g09, ncam, ncam1, wu:fj56g09, NCAM1, n-cam
Reactivity
»Alternatives Human, Primate
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
Application
»Alternatives Flow Cytometry (FACS)
Pubmed 6 references available
Catalog no. ABIN94191
Quantity 100 tests
Price
421.08 $   Plus shipping costs $45.00
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Availability Will be delivered in 4 to 5 Business Days
Immunogen KG-1 human acute myelogenous leukemia cell line
Clone MEM-188
Isotype IgG2a
Specificity The antibody MEM-188 reacts with a 180 kDa isoform of CD56 (NCAM) expressed inleukocytes. It has been suggested that the antibody MEM-188 could react with rhesusmonkey lymphocytes. Reactivity with other NCAM isoforms has not been tested.HLDA VI, WS code A055HLDA VI, WS Code NK26HLDA VII, WS code 70077
Alternative Name NCAM1
Background CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein ofimmunoglobulin family serving as adhesive molecule which is ubiquitously expressed innervous system, usually as 120 kDa, 140 kDa or 180 kDa isoform, and it is also found on Tcells and NK cells. Polysialic modification results in reduction of CD56-mediated celladhesion and is involved in cell migration, axonal growth, pathfinding and synaptic plasticity.CD56 is a widely used neuroendocrine marker with a high sensitivity for neuroendocrinetumours and ovarian granulosa cell tumours.
Research Area CD Antigens, Surface Receptors of Immune Cells, Signaling
Application Notes The reagent is designed for Flow Cytometry analysis of human blood cells using 10 µl reagent / 100 µl of whole blood or 10 6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Restrictions For Research Use only
Buffer The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azideand 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
Preservative Sodium azide
Storage 4 °C
Brdicka, Imrich, Angelisová et al.: "Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling." in: The Journal of experimental medicine, Vol. 196, Issue 12, pp. 1617-26, 2002 (PubMed).

Brdicková, Brdicka, Angelisová et al.: "LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling." in: The Journal of experimental medicine, Vol. 198, Issue 10, pp. 1453-62, 2003 (PubMed).

Lin, Liu, Chen et al.: "CD94 1A transcripts characterize lymphoblastic lymphoma/leukemia of immature natural killer cell origin with distinct clinical features." in: Blood, Vol. 106, Issue 10, pp. 3567-74, 2005 (PubMed).

Drbal, Moertelmaier, Holzhauser et al.: "Single-molecule microscopy reveals heterogeneous dynamics of lipid raft components upon TCR engagement." in: International immunology, Vol. 19, Issue 5, pp. 675-84, 2007 (PubMed).

Olsen, Tollefsen, Aagaard et al.: "Isolation of Mycobacterium avium subspecies paratuberculosis reactive CD4 T cells from intestinal biopsies of Crohn's disease patients." in: PLoS ONE, Vol. 4, Issue 5, pp. e5641, 2009 (PubMed).

Benson, Grobarova, Richter et al.: "Glycosylation regulates NK cell-mediated effector function through PI3K pathway." in: International immunology, Vol. 22, Issue 3, pp. 167-77, 2010 (PubMed).

Alternatives for antigen "Neural Cell Adhesion Molecule 1 (NCAM1)", type "Antibodies"
Hosts (302), (71), (4), (2), (1), (1)
Reactivities (350), (65), (61), (41), (41), (36), (36), (18), (17), (3), (2), (1), (1), (1)
Applications (219), (107), (95), (55), (49), (36), (35), (33), (28), (22), (20), (6), (5), (3), (1), (1), (1), (1)
Conjugates (29), (29), (27), (10), (7), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Epitopes (7), (4), (3), (3), (2), (2), (2), (2), (2), (1)
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