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Antibodies
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anti-Death-Domain Associated Protein (DAXX) antibody
Death-Domain Associated Protein (DAXX) antibody
| Antigen |
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| Synonyms |
DAP6, EAP1, BING2, MGC126245, MGC126246, MGC150289, DAP-3, 4921514D13Rik, im:6905684, LOC100226911 |
| Clonality |
Monoclonal (DAXX-01) |
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Host
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Reactivity
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Application
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 Alternatives Western Blotting (WB), Immunocytochemistry (ICC)
Western Blotting (WB) (51), Immunofluorescence (IF) (33), Flow Cytometry (FACS) (22), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (15), ELISA (14), Enzyme Immunoassay (EIA) (13), Immunoprecipitation (IP) (8), Immunohistochemistry (IHC) (6), Immunocytochemistry (ICC) (5), Immunohistochemistry (Frozen Sections) (IHC (fro)) (5), Dot Blot (Dot) (3), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), ELISA (Detection) (1), Immunoelectron Microscopy (IEM) (1)
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| Catalog no. |
ABIN94302 |
| Quantity |
0.1 mg (1 mg/ml) |
| Price |
286.00 $ Plus shipping costs $35.00
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| Shipping to |
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| Availability |
Ships within 3 to 5 Business Days |
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Alternative name
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Daxx
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Immunogen
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Recombinant C-terminal part (aa 558-740) of human Daxx.
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Format
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Purified
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Isotype
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IgG1 (Matching secondary antibodies)
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Clone
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DAXX-01
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Description
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Daxx is an apoptosis-modulating death domain-associated protein with functions intranscriptional regulation. Daxx functions bot in cytoplasm, where it interacts with Fas, andin nucleus (residing in PML oncogenic domains), where it is involved in SUMO-dependentregulation of transcription and subnuclear compartmentalization. Daxx senzitizes the cells toapoptosis, but on the other hand, this protein may also serve in preventing apoptosis in theearly embryo. Even regarding the transcription, Daxx can serve both as a corepressor and acoactivator. During ischemic stress, Daxx translocates from the nucleus to the cytoplasm,where in regulates sodium hydrogen exchanger isoform 1 (NHE1).
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Specificity
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The antibody DAXX-01 reacts with Daxx, a death domain containing protein mainlyexpressed in fetal and adult human and mouse tissue.
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Concentration
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1 mg/ml
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Purity
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> 95% (by SDS-PAGE)
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Purification
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Purified from ascites by protein-A affinity chromatography.
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Buffer
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Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
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Storage
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Store at 2-8 o C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20 o C. Avoid freeze/thaw cycles.
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Research Area
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Apoptosis/Necrosis
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Restrictions
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For Research Use only
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Alternatives for antigen "Death-Domain Associated Protein (DAXX)", type "Antibodies"
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Hosts
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Rabbit (56), Mouse (16)
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Reactivities
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Human (71), Mouse (Murine) (31), Rat (Rattus) (26), Cow (Bovine) (19), Dog (Canine) (16), Pig (Porcine) (16), Rabbit (16), Sheep (Ovine) (15), Monkey (5), Horse (Equine) (1)
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Applications
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Western Blotting (WB) (51), Immunofluorescence (IF) (33), Flow Cytometry (FACS) (22), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (15), ELISA (14), Enzyme Immunoassay (EIA) (13), Immunoprecipitation (IP) (8), Immunohistochemistry (IHC) (6), Immunocytochemistry (ICC) (5), Immunohistochemistry (Frozen Sections) (IHC (fro)) (5), Dot Blot (Dot) (3), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), ELISA (Detection) (1), Immunoelectron Microscopy (IEM) (1)
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Conjugates
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Alexa Fluor 488 (2), Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1)
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Epitopes
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C-Term (6), S495 (2), pSer213 (2), pSer495 (2), pSer517 (2), pSer671 (2), AA 272-291 (1), AA 561- 661 (1), S213 (1), S517 (1), pS671 (1)
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