ERI2 antibody (Middle Region)

Catalog No. ABIN952142

The Rabbit Polyclonal anti-ERI2 antibody has been validated for WB and EIA. It is suitable to detect ERI2 in samples from Human.

Quick Overview for ERI2 antibody (Middle Region) (ABIN952142)

Target: ERI2 (EXOD1) (ERI1 Exoribonuclease Family Member 2 (EXOD1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERI2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-ERI2 Antibody

Binding Specificity: AA 443-472, Middle Region

Specificity: This antibody recognizes Human EXOD1 (Center).

Purification: Affinity Chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 443-472 amino acids from the Central region of Human EXOD1 Genename: ERI2

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for ERI2

Target: ERI2 (EXOD1) (ERI1 Exoribonuclease Family Member 2 (EXOD1))

Alternative Name: EXOD1

Background: EXOD1 (Exonuclease domain-containing protein 1), also known as ERI2 (ERI1 exoribonuclease 2), is a 691 amino acid protein that contains one exonuclease domain, which catalyzes the hydrolysis of unpaired or mismatched nucleotides. EXOD1 acitivity is dependent on the binding of two magnesium ions per subunit. There are four isoforms of EXOD1 that are produced as a result of alternative splicing events. The gene encoding EXOD1 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3 % of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.Synonyms: Exonuclease domain-containing protein 1, KIAA1504, MGC16943

Molecular Weight: 77401 Da

Gene ID: 112479

NCBI Accession: NP_001136197