HDAC11 antibody (Middle Region)

Catalog No. ABIN952697

The Rabbit Polyclonal anti-HDAC11 antibody has been validated for WB and EIA. It is suitable to detect HDAC11 in samples from Human and Mouse.

Quick Overview for HDAC11 antibody (Middle Region) (ABIN952697)

Target: HDAC11 (Histone Deacetylase 11 (HDAC11))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDAC11 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-HDAC11 Antibody

Binding Specificity: AA 196-226, Middle Region

Specificity: This antibody recognizes Human and Mouse HDAC11 (Center).

Cross-Reactivity (Details): Species reactivity (expected):Monkey.

Purification: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 196-226 amino acids from the Central region of human HDAC11

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for HDAC11

Target: HDAC11 (Histone Deacetylase 11 (HDAC11))

Alternative Name: HDAC11

Background: This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants. Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Cellular Location: Nucleus. Note=Predominantly nuclear. Tissue Location: Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testisSynonyms: HD11, Histone deacetylase 11

Molecular Weight: 39183 Da

Gene ID: 79885

NCBI Accession: NP_079103