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Translin (TSN) (AA 116-146), (Middle Region) antibody

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Synonyms tsn, MGC52533, TSN, CG11761, Dmel\\CG11761, TB-RBP, BCLF-1, C3PO, RCHF1, REHF-1, TBRBP, TRSLN, 2610034C24Rik, AU040286
AA 116-146, Middle Region
(15), (15), (12), (7), (2), (1), (1), (1), (1), (1)
(44), (20), (16), (2)
(44), (1)
(2), (2), (2), (2), (2), (2)
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(41), (30), (26), (10), (6), (2), (1)
Pubmed 3 references available
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Quantity 0.4 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen KLH conjugated synthetic peptide between 116-146 amino acids from the Central region of human TSN
Isotype Ig
Specificity This antibody detects Translin (TSN).
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Protein A column followed by peptide affinity purification
Background This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms.
Gene ID 7247
NCBI Accession NP_004613
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Translin (TSN) (AA 116-146), (Middle Region) antibody (ABIN955319) TSN Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin em...
Western Blotting (WB) image for anti-Translin (TSN) (AA 116-146), (Middle Region) antibody (ABIN955319) TSN Antibody (Center) western blot analysis in Hela cell line lysates (35 µg/lane). T...
Background publications Chiaruttini, Vicario, Li et al.: "Dendritic trafficking of BDNF mRNA is mediated by translin and blocked by the G196A (Val66Met) mutation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 38, pp. 16481-6, 2009 (PubMed).

Lasky-Su, Neale, Franke et al.: "Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 147B, Issue 8, pp. 1345-54, 2008 (PubMed).

Sengupta, Kamdar, DSouza et al.: "GTP-induced conformational changes in translin: a comparison between human and Drosophila proteins." in: Biochemistry, Vol. 45, Issue 3, pp. 861-70, 2006 (PubMed).

Catalog No. ABIN955319
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