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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Adiponectin, C1Q and Collagen Domain Containing (ADIPOQ) (AA 55-69,N-Term) antibody
|Synonyms||ACDC, ADPN, APM1, APM-1, GBP28, ACRP30, ADIPQTL1, adiponectin, APN, Acdc, apM1, 30kDa, adipo, Acrp30, ADIPOQ, MGC138982, ADN, MGC84292|
Human, Mouse (Murine)
Alternatives Immunohistochemistry (IHC)
|6 references available|
|Price||316.25 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 5 to 7 Business Days|
|Immunogen||Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to residues 55-69 of human ADIPOQ(Adiponectin precursor)|
|Description||ADIPOQ (Adiponectin) is an important negative regulator in hematopoiesis and immunesystems. ADIPOQ may be involved in ending inflammatory responses through its inhibitory functions. ADIPOQ inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. It inhibits TNF-alpha-induced expression of endothelial adhesion molecules. ADIPOQ is involved in the control of fat metabolism and insulin sensitivity. Defects in ADIPOQ are the cause of adiponectin deficiency. The result is a very low concentration of plasma adiponectin. The decreased adiponectin plasma levels are associated with obesity insulin resistance, and diabetes type 2.|
|Application Notes||ELISA, Western blotting: 1µg/ml for 2hrs.|
|Purification||Purified by antigen-specific affinity chromatography.|
|Buffer||This antibody is stored in PBS, 50% glycerol|
|Preservative||0.01% Sodium Azide|
|Storage||Store at -20°C.|
|Restrictions||For Research Use only|
Nakano, Tobe, Choi-Miura et al.: "Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma." in: Journal of biochemistry, Vol. 120, Issue 4, pp. 803-12, 1997 (PubMed).
Arita, Kihara, Ouchi et al.: "Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity." in: Biochemical and biophysical research communications, Vol. 257, Issue 1, pp. 79-83, 1999 (PubMed).
Saito, Tobe, Minoshima et al.: "Organization of the gene for gelatin-binding protein (GBP28)." in: Gene, Vol. 229, Issue 1-2, pp. 67-73, 1999 (PubMed).
Schäffler, Orsó, Palitzsch et al.: "The human apM-1, an adipocyte-specific gene linked to the family of TNF's and to genes expressed in activated T cells, is mapped to chromosome 1q21.3-q23, a susceptibility locus identified for familial combined hyperlipidaemia (FCH)." in: Biochemical and biophysical research communications, Vol. 260, Issue 2, pp. 416-25, 1999 (PubMed).
Yokota, Oritani, Takahashi et al.: "Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages." in: Blood, Vol. 96, Issue 5, pp. 1723-32, 2000 (PubMed).
Ouchi, Kihara, Arita et al.: "Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway." in: Circulation, Vol. 102, Issue 11, pp. 1296-301, 2000 (PubMed).