BCL10 antibody

Catalog No. ABIN965650

This Monoclonal antibody specifically detects BCL10 in WB, IHC and ELISA. It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for BCL10 antibody (ABIN965650)

Target: BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

Reactivity: Human

Host: Please inquire

Clonality: Monoclonal

Conjugate: This BCL10 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-BCL10 Antibody

Specificity: Ni-NTA purified recombinant human BCL-10 expressed in E. Coli strain BL21 (DE3).

Purification: Antibodies are purified by protein A affinity chromatography

Isotype: IgG1

Application Details

Application Notes: IHC(P): Dilution 1: 100- 1: 500
IHC(F): Dilution 1: 200- 1: 1000
Western blot: Dilution 1: 2000- 1: 5000
ELISA: Propose dilution 1: 10000.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Storage: -20 °C

References for anti-BCL10 antibody (ABIN965650)

Cahill: "Vasoconstrictor responsiveness of portal hypertensive vessels." in: Clinical science (London, England : 1979), Vol. 96, Issue 1, pp. 3-4, (1999) (PubMed).

Target Details for BCL10

Target: BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

Alternative Name: BCL-10

Background: Bcl-10 is a 31kDa protein containing a caspase recruitment domain (CARD). It plays an important role in apoptosis and activating NF-kappaB. The research suggested that it interacted with other CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as upstream regulators in NF-kappaB signaling. Bcl10 is found to form a complex with MALT1 which encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.

Gene ID: 8915

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins