Caveolin-1 antibody

Catalog No. ABIN965753

There are 3+ publications for this product available. The Rabbit Polyclonal anti-Caveolin-1 antibody is suitable to detect Caveolin-1 in samples from Human, Rat and Mouse. It has been validated for IHC.

Quick Overview for Caveolin-1 antibody (ABIN965753)

Target: Caveolin-1 (CAV1) (Caveolin 1, Caveolae Protein, 22kDa (CAV1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caveolin-1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-Caveolin-1 Antibody

Specificity: Caveolin-1 (Ab-14) antibody detects endogenous levels of total Caveolin-1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human Caveolin-1 around the phosphorylation site of Tyrosine 14 (H-L-YP-T-V).

Application Details

Application Notes: WB: 1:500~1:1000.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 100ug/100ul.

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-Caveolin-1 antibody (ABIN965753)

Labrecque, Nyalendo, Langlois, Durocher, Roghi, Murphy, Gingras, Béliveau: "Src-mediated tyrosine phosphorylation of caveolin-1 induces its association with membrane type 1 matrix metalloproteinase." in: The Journal of biological chemistry, Vol. 279, Issue 50, pp. 52132-40, (2004) (PubMed).

Fielding, Chau, Liu, Spencer, Fielding: "Mechanism of platelet-derived growth factor-dependent caveolin-1 phosphorylation: relationship to sterol binding and the role of serine-80." in: Biochemistry, Vol. 43, Issue 9, pp. 2578-86, (2004) (PubMed).

Maggi, Biedi, Segat, Barbero, Panetta, Cordera: "IGF-I induces caveolin 1 tyrosine phosphorylation and translocation in the lipid rafts." in: Biochemical and biophysical research communications, Vol. 295, Issue 5, pp. 1085-9, (2002) (PubMed).

Target Details for Caveolin-1

Target: Caveolin-1 (CAV1) (Caveolin 1, Caveolae Protein, 22kDa (CAV1))

Alternative Name: Caveolin-1

Pathways: Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2, Negative Regulation of Transporter Activity, VEGFR1 Specific Signals