ER Degradation Enhancer, Mannosidase alpha-Like 1 (EDEM1) (C-Term) antibody

Details for Product No. ABIN966027
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Synonyms zgc:55816, edem, EDEM1, EDEM, A130059K23Rik, mKIAA0212, RGD1563633
(3), (3), (3), (1), (1), (1), (1)
Human, Mouse (Murine)
(11), (5), (3), (2), (1), (1), (1), (1), (1)
(9), (3)
Immunohistochemistry (IHC)
(12), (4)
Pubmed 2 references available
Quantity 0.1 mg
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human EDEM1(ER degradation-enhancing alpha-mannosidase-like 1)
Purification Purified by antigen-specific affinity chromatography.
Alternative Name EDEM1 (EDEM1 Antibody Abstract)
Background EDEM1(ER degradation-enhancing alpha-mannosidase-like 1) extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. It lacks mannosidase activity. EDEM1 is located in endoplasmic reticulum membrane and is a single-pass type II membrane protein. EDEM1 belongs to the glycosyl hydrolase 47 family.
Research Area Signaling
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Molinari, Calanca, Galli et al.: "Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle." in: Science (New York, N.Y.), Vol. 299, Issue 5611, pp. 1397-400, 2003 (PubMed).

Nagase, Seki, Ishikawa et al.: "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 3, Issue 5, pp. 321-9, 341-54, 1997 (PubMed).

Catalog No. ABIN966027
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