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ER Degradation Enhancer, Mannosidase alpha-Like 1 (EDEM1) (C-Term) antibody

Details for Product No. ABIN966027
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Antigen
Synonyms EDEM, A130059K23Rik, mKIAA0212, RGD1563633, zgc:55816, edem, EDEM1
Epitope
C-Term
(2), (2), (1)
Reactivity
Human, Mouse (Murine)
(7), (2), (2), (1), (1), (1)
Host
Rabbit
(7), (1)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC)
(7), (3), (1)
Pubmed 2 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN966027
316.25 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human EDEM1(ER degradation-enhancing alpha-mannosidase-like 1)
Purification Purified by antigen-specific affinity chromatography.
Alternative Name EDEM1
Background EDEM1(ER degradation-enhancing alpha-mannosidase-like 1) extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. It lacks mannosidase activity. EDEM1 is located in endoplasmic reticulum membrane and is a single-pass type II membrane protein. EDEM1 belongs to the glycosyl hydrolase 47 family.
Research Area Signaling
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Nagase, Seki, Ishikawa et al.: "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 3, Issue 5, pp. 321-9, 341-54, 1997 (PubMed).

Molinari, Calanca, Galli et al.: "Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle." in: Science (New York, N.Y.), Vol. 299, Issue 5611, pp. 1397-400, 2003 (PubMed).

Hosts (7), (1)
Reactivities (7), (2), (2), (1), (1), (1)
Applications (7), (3), (1)
Epitopes (2), (2), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN966027
316.25 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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