HHEX antibody (N-Term)

Catalog No. ABIN966283

This Rabbit Polyclonal antibody specifically detects HHEX in WB. It exhibits reactivity toward Human. It has been mentioned in 2+ publications

Quick Overview for HHEX antibody (N-Term) (ABIN966283)

Target: HHEX (Hematopoietically Expressed Homeobox (HHEX))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HHEX antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HHEX Antibody

Binding Specificity: N-Term

Cross-Reactivity: Mouse (Murine), Rat (Rattus)

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Hematopoietically-expressed homeobox protein HHEX(HHEX) detection. Tested with WB in Human, Mouse, Rat.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminal of human HHEX, different from the related mouse sequence by one amino acid.< br/>Immunogen was affinity purified.

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Sodium azide, Thimerosal (Merthiolate)

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.

References for anti-HHEX antibody (ABIN966283)

DElia, Tell, Russo, Arturi, Puglisi, Manfioletti, Gattei, Mack, Cataldi, Filetti, Di Loreto, Damante: "Expression and localization of the homeodomain-containing protein HEX in human thyroid tumors." in: The Journal of clinical endocrinology and metabolism, Vol. 87, Issue 3, pp. 1376-83, (2002) (PubMed).

Hromas, Radich, Collins: "PCR cloning of an orphan homeobox gene (PRH) preferentially expressed in myeloid and liver cells." in: Biochemical and biophysical research communications, Vol. 195, Issue 2, pp. 976-83, (1993) (PubMed).

Target Details for HHEX

Target: HHEX (Hematopoietically Expressed Homeobox (HHEX))

Alternative Name: Hematopoietically-expressed homeobox protein Hhex(Homeobox protein HEX)

Background: Hematopoietically-expressed homeobox protein HHEX is a protein that in humans is encoded by the HHEX gene. Homeobox genes are members of a family of transcription factors that regulate tissue development in many different organisms. Hromas et al. (1993) set out to identify homeobox genes that might play a role in hematopoiesis. And using somatic cell hybrid analysis, they mapped the HHEX gene to chromosome 10, where the HOX11 gene is located. Homeobox genes are involved in neoplastic transformation of both epithelial and hemopoietic tissues. The divergent homeobox gene HEX is expressed in the anterior visceral endoderm during early mouse development and in some adult tissues of endodermal origin, including liver and thyroid. D'Elia et al. ﾒs findings suggested that regulation of HEX entry in the nucleus of thyrocytes may represent a critical step during human thyroid tumorigenesis.