Add to Basket Bulk discount
Order hotline:
+1 404 474 4654
+1 888 205 9894 (TF)

Insulin Receptor Substrate 1 (IRS1) antibody

Antigen

Insulin Receptor Substrate 1 (IRS1)
Synonyms HIRS-1, G972R, IRS-1, IRS1IRM, irs1, MGC75645, IRS1
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human, Mouse (Murine), Rat (Rattus)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunohistochemistry (IHC)
3 references available
Catalog no. ABIN966418
Quantity 100ug  (100ug/100ul.)  (Variants)
Price 385.00 $   Plus shipping costs $45.00
Bulk discount
Shipping to
Availability Will be delivered in 5 to 7 Business Days

Additional Information
Application Details Publications Alternatives Variants back to top

Alternative name IRS-1
Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from human IRS-1 around the phosphorylation site of serine 636 (P-M-SP-P-K).
Specificity IRS-1 (Ab-636) antibody detects endogenous levels of total IRS-1 protein.

Application Details
Publications Alternatives Variants back to top

Application Notes IHC: 1:50-1:100.
Concentration 100ug/100ul.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative 0.02% Sodium Azide
Storage Store at -20°C/1 year.
Restrictions For Research Use only

Publications
Application Details Alternatives Variants back to top

Product Kadowaki: "Insights into insulin resistance and type 2 diabetes from knockout mouse models." in: The Journal of clinical investigation, Vol. 106, Issue 4, pp. 459-65, 2000 (PubMed).

Ozes, Akca, Mayo et al.: "A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 8, pp. 4640-5, 2001 (PubMed).

Tzatsos, Kandror: "Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation." in: Molecular and cellular biology, Vol. 26, Issue 1, pp. 63-76, 2005 (PubMed).

Alternatives
Application Details Publications Variants back to top

Alternatives for antigen "Insulin Receptor Substrate 1 (IRS1)", type "Antibodies"
Hosts Rabbit (402), Mouse (13)
Reactivities Human (397), Rat (Rattus) (331), Mouse (Murine) (329), Pig (Porcine) (198), Cow (Bovine) (181), Dog (Canine) (146), Horse (Equine) (145), Chicken (110), Guinea Pig (54), Sheep (Ovine) (36), Cat (Feline) (1)
Applications Immunofluorescence (IF) (220), Western Blotting (WB) (173), ELISA (107), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (74), Immunohistochemistry (IHC) (68), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (36), Immunoprecipitation (IP) (28), Immunocytochemistry (ICC) (21), Immunoelectron Microscopy (IEM) (12), Dot Blot (Dot) (3), Dot Blot (DB) (1), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)
Conjugates Biotin (13), Alexa Fluor 350 (12), Alexa Fluor 488 (12), Alexa Fluor 555 (12), Alexa Fluor 647 (12), Cy3 (12), Cy5 (12), Cy5.5 (12), Cy7 (12), FITC (12), Gold (12), HRP (12), PE (12), PE,Cy3 (12), PE,Cy5 (12), PE,Cy5.5 (12), PE,Cy7 (12)
Epitopes pSer307 (32), pSer312 (29), C-Term (27), pSer612 (24), pSer1101 (19), pSer302 (19), pSer789 (19), pTyr1222 (18), pTyr895 (18), pSer639 (14), pSer176 (13), pSer332,pSer336 (13), pSer636 (13), pSer636,pSer639 (13), Internal Region (9), pTyr896 (6), pTyr896,C-Term (6), AA 1223-1242 (5), Ser639 (5), pSer336,pSer332 (5), pSer639,pSer636 (5), pThr176 (5), pSer616 (4), pTyr1179 (4), Ser636 (3), pSer312,Internal Region (3), pTyr941 (3), pSer1 (2), pTyr1229 (2), pTyr612 (2), AA 1220-1235 (1), AA 1222-1235 (1), AA 298-316,pSer307 (1), AA 431-446 (1), AA 801-1020 (1), AA 969-998 (1), Middle Region (1), Ser312 (1), pSer323 (1), pSer636, pSer639 (1), pSer794 (1), pThr1179 (1), pTyr989 (1)