Insulin Receptor Substrate 1 (IRS1) antibody

Details for Product No. ABIN966418
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Antigen
Synonyms HIRS-1, G972R, IRS-1, IRS1IRM, irs1, irsu, IRS1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(455), (356), (338), (132), (121), (97), (76), (36), (1)
Host
Rabbit
(470), (15)
Clonality
Polyclonal
Conjugate
Un-conjugated
(13), (12), (12), (12), (12), (12), (12), (12), (12), (12), (12)
Application
Immunohistochemistry (IHC)
(276), (174), (145), (120), (97), (75), (44), (23), (7), (4), (1), (1)
Pubmed 3 references available
Catalog no. ABIN966418
Quantity 100 µg
Price
385.00 $   Plus shipping costs $45.00
Options
Shipping to United States (Change)
Availability Will be delivered in 5 to 7 Business Days

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Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from human IRS-1 around the phosphorylation site of serine 636 (P-M-SP-P-K).
Specificity IRS-1 (Ab-636) antibody detects endogenous levels of total IRS-1 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Alternative Name IRS-1
Application Notes IHC: 1:50-1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Storage -20 °C
Product cited in: Kadowaki: "Insights into insulin resistance and type 2 diabetes from knockout mouse models." in: The Journal of clinical investigation, Vol. 106, Issue 4, pp. 459-65, 2000 (PubMed).

Ozes, Akca, Mayo et al.: "A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 8, pp. 4640-5, 2001 (PubMed).

Tzatsos, Kandror: "Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation." in: Molecular and cellular biology, Vol. 26, Issue 1, pp. 63-76, 2005 (PubMed).

Hosts (470), (15)
Reactivities (455), (356), (338), (132), (121), (97), (76), (36), (1)
Applications (276), (174), (145), (120), (97), (75), (44), (23), (7), (4), (1), (1)
Conjugates (13), (12), (12), (12), (12), (12), (12), (12), (12), (12), (12)
Epitopes (42), (41), (38), (37), (23), (18), (17), (17), (16), (14), (13), (13), (12), (12), (12), (12), (8), (6), (6), (5), (4), (4), (4), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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