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Insulin Receptor Substrate 1 (IRS1) antibody

Details for Product No. ABIN966418, Supplier: Login to see New
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Synonyms irs1, irsu, IRS1, HIRS-1, G972R, IRS-1, IRS1IRM, irs-1, irs1-a
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Human, Mouse (Murine), Rat (Rattus)
(536), (353), (336), (10), (9), (5), (1), (1)
(533), (30)
(13), (12), (11), (11), (11), (10), (10), (10), (10), (10), (10), (10), (2), (1), (1), (1)
Immunohistochemistry (IHC)
(333), (221), (140), (112), (103), (85), (34), (32), (11), (4), (2), (1)
Pubmed 3 references available
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Quantity 100 μg
Shipping to United States ( )
Availability Will be delivered in 5 to 7 Business Days
Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from human IRS-1 around the phosphorylation site of serine 636 (P-M-SP-P-K).
Specificity IRS-1 (Ab-636) antibody detects endogenous levels of total IRS-1 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Alternative Name IRS-1 (IRS1 Antibody Abstract)
Pathways Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes IHC: 1:50-1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Tzatsos, Kandror: "Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation." in: Molecular and cellular biology, Vol. 26, Issue 1, pp. 63-76, 2005 (PubMed).

Kadowaki: "Insights into insulin resistance and type 2 diabetes from knockout mouse models." in: The Journal of clinical investigation, Vol. 106, Issue 4, pp. 459-65, 2000 (PubMed).

Background publications Ozes, Akca, Mayo et al.: "A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 8, pp. 4640-5, 2001 (PubMed).

Catalog No. ABIN966418
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