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Orthodenticle Homeobox 2 (OTX2) antibody

Details for Product No. ABIN966720, Supplier: Login to see
Antigen
  • CPHD6
  • MCOPS5
  • Xotx-2
  • Xotx2
  • otx-2
  • otx2
  • id:ibd2915
  • zOtx2
  • zgc:136535
  • zotx-2
  • E130306E05Rik
Reactivity
Human
82
26
23
3
3
3
3
2
2
1
Host
Mouse
63
18
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
4
4
4
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
63
31
25
11
11
8
6
5
4
2
1
Supplier
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Immunogen Purified recombinant fragment of human OTX2 expressed in E. Coli.
Clone 1H12C4B5
Isotype IgG1
Purification Ascitic fluid
Alternative Name OTX2 (OTX2 Antibody Abstract)
Background This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mice is required for proper forebrain development.
Tissue specificity: Expressed in brain.
Synonyms: MCOPS5, MGC45000
Molecular Weight 32kDa
Gene ID 5015
Pathways
Application Notes Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
Immunofluorescence: 1/200 - 1/1000.
Flow cytometry: 1/200 - 1/400.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Adamson, Shi, Wortham et al.: "OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas." in: Cancer research, Vol. 70, Issue 1, pp. 181-91, 2010 (PubMed).

Background publications Wyatt, Bakrania, Bunyan et al.: "Novel heterozygous OTX2 mutations and whole gene deletions in anophthalmia, microphthalmia and coloboma." in: Human mutation, Vol. 29, Issue 11, pp. E278-83, 2008 (PubMed).