DOK1 antibody

Catalog No. ABIN966766

This Rabbit Polyclonal antibody specifically detects DOK1 in IHC. It exhibits reactivity toward Human, Mouse and Rat and has been mentioned in 4+ publications.

Quick Overview for DOK1 antibody (ABIN966766)

Target: DOK1 (Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) (DOK1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DOK1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-DOK1 Antibody

Specificity: P62Dok (Ab-362) antibody detects endogenous levels of total p62Dok protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human p62Dok around the phosphorylation site of tyrosine 362 (P-I-YP-D-E).

Application Details

Application Notes: WB: 1:500~1:1000
IHC: 1:50~1:100.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 100ug/100ul.

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-DOK1 antibody (ABIN966766)

Kato, Takai, Kudo: "The pre-B cell receptor signaling for apoptosis is negatively regulated by Fc gamma RIIB." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 2, pp. 629-34, (2002) (PubMed).

Songyang, Yamanashi, Liu, Baltimore: "Domain-dependent function of the rasGAP-binding protein p62Dok in cell signaling." in: The Journal of biological chemistry, Vol. 276, Issue 4, pp. 2459-65, (2001) (PubMed).

Némorin, Duplay: "Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling." in: The Journal of biological chemistry, Vol. 275, Issue 19, pp. 14590-7, (2000) (PubMed).

Tanaka, Kami, Ogawa, Machida, Takahashi, Ichikawa, Yuji, Izutsu, Asai, Kanda, Honda, Mitani, Chiba, Hirai, Yazaki, Sasaki, Sasaki, Mineishi: "Hyperacute graft-versus-host disease and NKT cells." in: American journal of hematology, Vol. 63, Issue 1, pp. 60-1, (2000) (PubMed).

Target Details for DOK1

Target: DOK1 (Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) (DOK1))

Alternative Name: p62Dok