TNFRSF11A antibody (N-Term)

Catalog No. ABIN966946

This Polyclonal antibody specifically detects TNFRSF11A in WB. It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for TNFRSF11A antibody (N-Term) (ABIN966946)

Target: TNFRSF11A (Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A))

Reactivity: Human

Host: Please inquire

Clonality: Polyclonal

Conjugate: This TNFRSF11A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TNFRSF11A Antibody

Binding Specificity: AA 29-44, N-Term

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminal of human RANK (29-44 aa), identical to the related mouse and rat sequence.

Application Details

Application Notes: WB: The detection limit for RANK is approximately 2.5ng/lane under non-reducing and reducing conditions.

Restrictions: For Research Use only

Handling

Reconstitution: 0.2ml of distilled water will yield a concentration of 500µg/ml.

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4

Preservative: Thimerosal (Merthiolate), Sodium azide

Storage: -20 °C

References for anti-TNFRSF11A antibody (ABIN966946)

Theill, Boyle, Penninger: "RANK-L and RANK: T cells, bone loss, and mammalian evolution." in: Annual review of immunology, Vol. 20, pp. 795-823, (2002) (PubMed).

Suda, Takahashi, Udagawa, Jimi, Gillespie, Martin: "Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families." in: Endocrine reviews, Vol. 20, Issue 3, pp. 345-57, (1999) (PubMed).

Target Details for TNFRSF11A

Target: TNFRSF11A (Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A))

Alternative Name: RANK

Background: Receptor Activator of Nuclear Factor B (RANK), also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is also expressed on dendritic cells and facilitates immune signaling.RANKL (Receptor Activator for Nuclear Factor B Ligand) is found on the surface of stromal cells, osteoblasts, and T cells. By analysis of somatic cell and radiation hybrid panels, Anderson et al. (1997) mapped the RANK gene to 18q22.1.

Pathways: NF-kappaB Signaling