RANK (CD265) (N-Term,AA 29-44) antibody

Antigen: RANK (CD265)

Binding Site: N-Term,AA 29-44

Clonality: Polyclonal

Host: Please enquire

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Catalog no.: ABIN966946

Additional Information

Alternative name: RANK

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminal of human RANK (29-44 aa), identical to the related mouse and rat sequence.

Reconstitution: 0.2ml of distilled water will yield a concentration of 500µg/ml.

Description: Receptor Activator of Nuclear Factor B (RANK), also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is also expressed on dendritic cells and facilitates immune signaling.RANKL (Receptor Activator for Nuclear Factor B Ligand) is found on the surface of stromal cells, osteoblasts, and T cells. By analysis of somatic cell and radiation hybrid panels, Anderson et al. (1997) mapped the RANK gene to 18q22.1.

Application Details

Application Notes: WB: The detection limit for RANK is approximately 2.5ng/lane under non-reducing and reducing conditions.

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4

Preservative: 0.05mg Thiomersal, 0.05mg NaN3.

Storage: At -20°C for one year. After reconstitution, at 4°C for one month.

Research Area: Cardiovascular, Atherosclerosis, Extracellular Matrix, Innate Immunity, Cytokines

Restrictions: For Research Use only

Publications

Product: Suda, Takahashi, Udagawa et al.: "Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families." in: Endocrine reviews, Vol. 20, Issue 3, pp. 345-57, 1999 (PubMed).

Wong, Josien, Choi: "TRANCE is a TNF family member that regulates dendritic cell and osteoclast function." in: Journal of leukocyte biology, Vol. 65, Issue 6, pp. 715-24, 1999 (PubMed).

Theill, Boyle, Penninger: "RANK-L and RANK: T cells, bone loss, and mammalian evolution." in: Annual review of immunology, Vol. 20, pp. 795-823, 2002 (PubMed).