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Tripartite Motif Containing 25 (TRIM25) (N-Term) antibody

Details for Product No. ABIN967205, Supplier: Login to see
Antigen
  • zgc:55773
  • MGC130751
  • EFP
  • RNF147
  • Z147
  • ZNF147
  • AA960166
  • AL022677
  • Zfp147
  • Efp
  • Znf147
Epitope
N-Term
18
15
14
14
12
11
10
5
5
4
3
3
2
2
2
1
1
1
1
1
1
1
Reactivity
Human
120
31
18
1
1
1
1
1
1
Host
Rabbit
107
13
Clonality
Polyclonal
Conjugate
Un-conjugated
4
4
4
3
2
2
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (IHC)
89
50
24
21
16
16
12
6
3
2
2
Supplier
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human TRIM25 (Tripartite motif-containing protein 25)
Alternative Name TRIM25 (TRIM25 Antibody Abstract)
Background TRIM25 (Tripartite motif-containing protein 25) is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a Bbox type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of TRIM25 is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary TRIM25 contains 1 B30.2/SPRY domain and 1 RING-type zinc finger.
Synonyms: EFP (Estrogen-responsive finger protein), RNF147 (RING finger protein 147), ZNF147(Zinc finger protein 147)
Pathways
Restrictions For Research Use only
Product cited in: Inoue, Orimo, Hosoi et al.: "Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 23, pp. 11117-21, 1994 (PubMed).

Background publications Dephoure, Zhou, Villén et al.: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008 (PubMed).

Rush, Moritz, Lee et al.: "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." in: Nature biotechnology, Vol. 23, Issue 1, pp. 94-101, 2005 (PubMed).