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TYK2 antibody (Tyrosine Kinase 2)

Details for Product anti-TYK2 Antibody No. ABIN967219, Supplier: Log in to see
Antigen
  • JTK1
Alternatives
anti-Human TYK2 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
160
62
48
1
Host
Rabbit
135
25
Clonality
Polyclonal
Conjugate
This TYK2 antibody is un-conjugated
6
6
6
4
4
4
3
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (IHC)
91
59
51
24
22
20
8
3
1
1
1
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Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from human TYK2 around the phosphorylation site of tyrosine 1054 (H-E-YP-Y-R).
Specificity TYK2 (Ab-1054) antibody detects endogenous levels of TYK2 protein around tyrosine 1054.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Alternative Name Tyk2 (TYK2 Antibody Abstract)
Pathways JAK-STAT Signaling
Application Notes IHC: 1:50-1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Zheng, Hu, Quinn et al.: "Phosphotyrosine proteomic study of interferon alpha signaling pathway using a combination of immunoprecipitation and immobilized metal affinity chromatography." in: Molecular & cellular proteomics : MCP, Vol. 4, Issue 6, pp. 721-30, 2005 (PubMed).

Gauzzi, Velazquez, McKendry et al.: "Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase." in: The Journal of biological chemistry, Vol. 271, Issue 34, pp. 20494-500, 1996 (PubMed).