SLC39A4 antibody (C-Term)

Catalog No. ABIN967274

There are 3+ publications for this product available. The Rabbit Polyclonal anti-SLC39A4 antibody is suitable to detect SLC39A4 in samples from Human. It has been validated for IHC.

Quick Overview for SLC39A4 antibody (C-Term) (ABIN967274)

Target: SLC39A4 (Solute Carrier Family 39 (Zinc Transporter), Member 4 (SLC39A4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC39A4 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-SLC39A4 Antibody

Binding Specificity: C-Term

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human ZIP4 (Zinc transporter ZIP4)

Application Details

Restrictions: For Research Use only

Handling

Storage: 4 °C

References for anti-SLC39A4 antibody (ABIN967274)

Kim, Wang, Dufner-Beattie, Andrews, Eide, Petris: "Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane." in: The Journal of biological chemistry, Vol. 279, Issue 6, pp. 4523-30, (2004) (PubMed).

Küry, Dréno, Bézieau, Giraudet, Kharfi, Kamoun, Moisan: "Identification of SLC39A4, a gene involved in acrodermatitis enteropathica." in: Nature genetics, Vol. 31, Issue 3, pp. 239-40, (2002) (PubMed).

Wang, Zhou, Kuo, Zemansky, Gitschier: "A novel member of a zinc transporter family is defective in acrodermatitis enteropathica." in: American journal of human genetics, Vol. 71, Issue 1, pp. 66-73, (2002) (PubMed).

Target Details for SLC39A4

Target: SLC39A4 (Solute Carrier Family 39 (Zinc Transporter), Member 4 (SLC39A4))

Alternative Name: ZIP4

Background: ZIP4 (Zinc transporter ZIP4) plays an important role in cellular zinc homeostasis as a zinc transporter. ZIP4 is regulated in response to zinc availability. ZIP4 is a multi-pass membrane protein and is colocalized with TFRC in the recycling endosomes. ZIP4 cycles between endosomal compartments and the plasma membrane in response to zinc availability. ZIP4 is highly expressed in kidney, small intestine, stomach, colon, jejunum and duodenum. Defects in SLC39A4 are the cause of acrodermatitis enteropathica zinc-deficiency type (AEZ). AEZ is a rare autosomal recessive disease caused by the inability to absorb sufficient zinc. The clinicals features are growth retardation, immune system dysfunction, alopecia, severe dermatitis, diarrhea and occasionally mental disorders. All these manifestations are reversible with zinc supplementation. Without zinc therapy this disease is fatal. ZIP4 belongs to the ZIP transporter (TC 2.A.5) family.
Synonyms: SLC39A4 (Solute carrier family 39 member 4), ZIP-4 (Zrt- and Irt-like protein 4)

Pathways: Transition Metal Ion Homeostasis, Autophagy