SRY (Sex Determining Region Y)-Box 17 (SOX17) antibody

Details for Product No. ABIN967681
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Synonyms sox17, Xsox17, sox17beta, sox17-beta, tSox17beta, Xsox17-beta, SOX17, Sox17alpha, Xsox17-alpha, Xsox17alpha, sox17-alpha, tSox17alpha, xSox17alpha1, xSox17alpha2, xsox17a, sox7/17, VUR3, Sox
(89), (23), (18), (9), (3), (2), (2), (1), (1), (1), (1)
(40), (36), (21)
Clonality (Clone)
Monoclonal ()
(3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
BioImaging (BI), Immunofluorescence (IF), Intracellular Staining (ICS), Western Blotting (WB)
(49), (30), (22), (16), (15), (14), (10), (8), (7), (6), (3), (1)
Pubmed 6 references available
Quantity 0.1 mg
Shipping to United States ( )
Brand BD Pharmingen™
Immunogen Human Sox17 Recombinant Protein
Clone P7-969
Isotype IgG1, kappa
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. An isotype control should be used at the same concentration as the antibody of interest.
3. Please refer to us for technical protocols.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
5. Sodium azide is a reversible inhibitor of oxidative metabolism, therefore, antibody preparations containing this preservative agent must not be used in cell cultures nor injected into animals. Sodium azide may be removed by washing stained cells or plate-bound antibody or dialyzing soluble antibody in sodium azide-free buffer. Since endotoxin may also affect the results of functional studies, we recommend the NA/LE (No Azide/Low Endotoxin) antibody format, if available, for in vitro and in vivo use.
6. Triton is a trademark of the Dow Chemical Company.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name SOX17 (SOX17 Antibody Abstract)
Background The P7-969 monoclonal antibody reacts with human Sox17, a member of the SOX (SRY-releated HMG-box) family of transcription factors. SOX family members contain a DNA binding domain (HMG-box) and are involved in the control of development. Sox17 is expressed in primitive and definitive endoderm and regulates fetal and neonatal hematopoietic stem cell proliferation.
Synonyms: SOX-17, SOX17, FLJ22252
Molecular Weight 45 kDa
Gene ID 64321
Research Area Embryogenesis, Embryonic stem cells, Transcription Factors

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store undiluted at 4°C.
Supplier Images
Western Blotting (WB) image for anti-SRY (Sex Determining Region Y)-Box 17 (SOX17) antibody (ABIN967681) Western blot analysis of Sox17 in definitive endoderm derived from human embryonic st...
Flow Cytometry (FACS) image for anti-SRY (Sex Determining Region Y)-Box 17 (SOX17) antibody (ABIN967681) Flow cytometric analysis of Sox17 in definitive endoderm derived from human embryonic...
Immunofluorescence (IF) image for anti-SRY (Sex Determining Region Y)-Box 17 (SOX17) antibody (ABIN967681) Immunofluorescent staining of Sox17 in definitive endoderm derived from human embryon...
Product cited in: Serrano, Gandillet, Pearson et al.: "Contrasting effects of Sox17- and Sox18-sustained expression at the onset of blood specification." in: Blood, Vol. 115, Issue 19, pp. 3895-8, 2010 (PubMed).

Séguin, Draper, Nagy et al.: "Establishment of endoderm progenitors by SOX transcription factor expression in human embryonic stem cells." in: Cell stem cell, Vol. 3, Issue 2, pp. 182-95, 2008 (PubMed).

Kim, Saunders, Morrison: "Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells." in: Cell, Vol. 130, Issue 3, pp. 470-83, 2007 (PubMed).

Collet, Secombes: "Construction and analysis of a secreting expression vector for fish cells." in: Vaccine, Vol. 23, Issue 13, pp. 1534-9, 2005 (PubMed).

Katoh: "Molecular cloning and characterization of human SOX17." in: International journal of molecular medicine, Vol. 9, Issue 2, pp. 153-7, 2002 (PubMed).

Background publications DAmour, Agulnick, Eliazer et al.: "Efficient differentiation of human embryonic stem cells to definitive endoderm." in: Nature biotechnology, Vol. 23, Issue 12, pp. 1534-41, 2005 (PubMed).

Catalog No. ABIN967681
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