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Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) (C-Term) antibody

Antigen

Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1)
Synonyms uvo, lcam, E-Cad, XBcad, l-cam, xcdh1, cdhc-A, xb-cad, XTCAD-1, E-cadherin, cadherin-1, uvomorulin, XB-cadherin, cdh1
Binding Site
Alternatives

C-Term
Clonality Monoclonal (36)
Host
Alternatives

Mouse
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP)
5 references available
Catalog no. ABIN967800
Quantity
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anti-Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) (C-Term) antibody

anti-Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) (C-Term) antibody (2)

Additional Information
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Alternative name E-Cadherin
Immunogen Human E-Cadherin Recombinant Protein
Cross-Reactivity Dog (Canine), Mouse (Murine), Rat (Rattus)
Format Liquid
Isotype IgG2a, kappa
Clone 36
Description E-Cadherin is a 120-kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with cortical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression. The 36/E-Cadherin monoclonal antibody recognizes the cytoplasmic domain of E-Cadherin, regardless of phosphorylation status. The peptide immunogen was generated from human E-Cadherin aa. 735-883.
Synonyms: CD324, CDH1, CADH1, Cadherin-1, ECAD, CDHE, Arc-1, LCAM, UVO, Uvomorulin
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Molecular Weight 120 kDa
Comments

Related Products: ABIN968533, ABIN967389

Application Details
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Concentration 250 µg/ml
Purity Purified
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative 0.09% Sodium azide.
Storage Store undiluted at -20°C.
Restrictions For Research Use only

Publications
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Product Takeichi: "The cadherins: cell-cell adhesion molecules controlling animal morphogenesis." in: Development (Cambridge, England), Vol. 102, Issue 4, pp. 639-55, 1988 (PubMed).

Jaksits, Kriehuber, Charbonnier et al.: "CD34+ cell-derived CD14+ precursor cells develop into Langerhans cells in a TGF-beta 1-dependent manner." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 9, pp. 4869-77, 1999 (PubMed).

Sheibani, Sorenson, Frazier: "Differential modulation of cadherin-mediated cell-cell adhesion by platelet endothelial cell adhesion molecule-1 isoforms through activation of extracellular regulated kinases." in: Molecular biology of the cell, Vol. 11, Issue 8, pp. 2793-802, 2000 (PubMed).

Miyoshi, Shillingford, Smith et al.: "Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium." in: The Journal of cell biology, Vol. 155, Issue 4, pp. 531-42, 2001 (PubMed).

Weng, Xin, Pablo et al.: "Protection against anoikis and down-regulation of cadherin expression by a regulatable beta-catenin protein." in: The Journal of biological chemistry, Vol. 277, Issue 21, pp. 18677-86, 2002 (PubMed).

Alternatives
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Alternatives for antigen "Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1)", type "Antibodies"
Hosts Mouse (94), Rabbit (90), Rat (7), Goat (5), Chicken (2)
Reactivities Human (171), Mouse (Murine) (62), Rat (Rattus) (52), Cow (Bovine) (39), Pig (Porcine) (39), Horse (Equine) (36), Dog (Canine) (26), Chicken (19), Rabbit (19), Monkey (10), Cat (Feline) (1)
Applications Western Blotting (WB) (123), Flow Cytometry (FACS) (52), ELISA (50), Immunofluorescence (IF) (47), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (45), Immunohistochemistry (IHC) (33), Immunoprecipitation (IP) (27), Immunocytochemistry (ICC) (17), Immunohistochemistry (Frozen Sections) (IHC (fro)) (13), Immunohistochemistry (Fixed) (IHC (fx)) (12), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (8), Functional Studies (Func) (6), Immunoelectron Microscopy (IEM) (2), Proximity Ligation Assay (PLA) (1)
Conjugates FITC (10), Biotin (9), APC (4), PE (4), Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), Gold (2), HRP (2), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), PE-Cy3 (1), PE-Cy5 (1), PE-Cy5.5 (1), PE-Cy7 (1), Un-conjugated (1)
Epitopes N-Term (7), C-Term (6), AA 600-707 (2), AA 662-675 (2), Cytoplasmic Domain (2), Internal Region (2), AA 441-523 (1), Internal Region,AA 662-675 (1), pSer838, pSer840 (1)