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Details for Product No. ABIN967800

Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) (C-Term) antibody

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Antigen
Synonyms
UVO, CDHE, ECAD, LCAM, Arc-1, CD324, arc-1, cd324, cdhe, ecad, lcam, uvo, AA960649, E-cad, Ecad, L-CAM, Um, E-cadherin, E-Cad, XB-cadherin, XBcad, XTCAD-1, b-cadherin, cadherin-1, cdh1-a, cdhc-A, cdhp ... show more
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP)
Pubmed 5 references available
Catalog no. ABIN967800
Quantity 50 µg
Price
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Immunogen Human E-Cadherin Recombinant Protein
Clone L22FA2
Isotype IgG2a, kappa
Cross-Reactivity Dog (Canine), Mouse (Murine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name E-Cadherin
Background E-Cadherin is a 120-kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with cortical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression. The 36/E-Cadherin monoclonal antibody recognizes the cytoplasmic domain of E-Cadherin, regardless of phosphorylation status. The peptide immunogen was generated from human E-Cadherin aa. 735-883.
Synonyms: CD324, CDH1, CADH1, Cadherin-1, ECAD, CDHE, Arc-1, LCAM, UVO, Uvomorulin
Molecular Weight 120 kDa
Comment

Related Products: ABIN968533, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Takeichi: "The cadherins: cell-cell adhesion molecules controlling animal morphogenesis." in: Development (Cambridge, England), Vol. 102, Issue 4, pp. 639-55, 1988 (PubMed).

Jaksits, Kriehuber, Charbonnier et al.: "CD34+ cell-derived CD14+ precursor cells develop into Langerhans cells in a TGF-beta 1-dependent manner." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 9, pp. 4869-77, 1999 (PubMed).

Sheibani, Sorenson, Frazier: "Differential modulation of cadherin-mediated cell-cell adhesion by platelet endothelial cell adhesion molecule-1 isoforms through activation of extracellular regulated kinases." in: Molecular biology of the cell, Vol. 11, Issue 8, pp. 2793-802, 2000 (PubMed).

Miyoshi, Shillingford, Smith et al.: "Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium." in: The Journal of cell biology, Vol. 155, Issue 4, pp. 531-42, 2001 (PubMed).

Weng, Xin, Pablo et al.: "Protection against anoikis and down-regulation of cadherin expression by a regulatable beta-catenin protein." in: The Journal of biological chemistry, Vol. 277, Issue 21, pp. 18677-86, 2002 (PubMed).

Alternatives for antigen "Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1)", type "Antibodies"
Hosts (136), (132), (9), (5), (4)
Reactivities (253), (95), (67), (34), (34), (24), (20), (19), (15), (14), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Applications (182), (80), (64), (62), (43), (36), (34), (31), (31), (31), (12), (8), (6), (3), (2), (1), (1), (1)
Conjugates (11), (8), (5), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1), (1)
Epitopes (14), (14), (12), (10), (8), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
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