Search, Find and Buy Antibodies, ELISA Kits and Proteins.
Loading Loading
Add to Basket
Order hotline:
phone +1 404 474 4654
fax +1 888 205 9894 (TF)
Details for Product No. ABIN967901

Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) (AA 1-219) antibody

Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

xcpp32, Lice, CPP32, SCA-1, CPP32B, CC3, CG14902, Cas3, Casp 3, Casp3, Caspase-3, DECAY, Decay, Dmel\\CG14902, Drosophila executioner caspase related to Apopain/Yama, caspase 3, caspase-3, CG7788, DRI ... show more
»Alternatives AA 1-219
»Alternatives Human
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), Immunoprecipitation (IP), Fluorescence Microscopy (FM)
Pubmed 5 references available
Catalog no. ABIN967901
Quantity 50 µg
Contact our Customer Service for availability and price in your country.
Shipping to
Immunogen Human CPP32
Clone Hs-3
Isotype IgG2a
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name Caspase-3
Background Apoptosis, a selective process of genetically programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptotic cells are characterized by loss of cell volume, plasma membrane blebbing, nuclear condensation, chromatin aggregation, and endonucleocytic degradation of DNA into nucleosomal fragments. Caspase-3 (CPP32, Yama, apopain) is a member of the family of cysteine proteases which includes interleukin-1beta converting enzyme (ICE) and C. elegans protein, Ced-3. An apoptotic signal such as granzyme B of cytotoxic T-cells (CTLs) or ICE-like proteases induces the intracellular cleavage of Caspase-3 from the inactive pro-form (32 kDa) to the active form which consists of the p20, p17, and p12 subunits. The active form of Caspase-3 cleaves several other apoptotic proteins including proteins such as DNA Fragmentation Factor (DFF). Apoptosis can be inhibited by coexpression of Bcl-2 as well as inhibitors of Caspase-3 or other members of the family of cysteine proteases. This antibody recognizes the human pro-form (inactive) of Caspase-3 at 32 kDa. In addition, it has been reported to recognize the active form of Caspase-3 at 20-21 kD in apoptotic cell lysates.
Synonyms: CPP32
Molecular Weight 32 kDa
Research Area Apoptosis/Necrosis, Autophagy

Related Products: ABIN968537, ABIN967389, ABIN967299

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Fernandes-Alnemri, Litwack, Alnemri: "CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme." in: The Journal of biological chemistry, Vol. 269, Issue 49, pp. 30761-4, 1995 (PubMed).

Scaffidi, Fulda, Srinivasan et al.: "Two CD95 (APO-1/Fas) signaling pathways." in: The EMBO journal, Vol. 17, Issue 6, pp. 1675-87, 1998 (PubMed).

Donoghue, Baden, Lauder et al.: "Immunohistochemical localization of caspase-3 correlates with clinical outcome in B-cell diffuse large-cell lymphoma." in: Cancer research, Vol. 59, Issue 20, pp. 5386-91, 1999 (PubMed).

Li, Chen, Sinogeeva et al.: "Arsenic trioxide promotes histone H3 phosphoacetylation at the chromatin of CASPASE-10 in acute promyelocytic leukemia cells." in: The Journal of biological chemistry, Vol. 277, Issue 51, pp. 49504-10, 2002 (PubMed).

Takemoto, Nagai, Miyawaki et al.: "Spatio-temporal activation of caspase revealed by indicator that is insensitive to environmental effects." in: The Journal of cell biology, Vol. 160, Issue 2, pp. 235-43, 2003 (PubMed).

Alternatives for antigen "Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3)", type "Antibodies"
Hosts (233), (58), (7), (2)
Reactivities (276), (94), (84), (25), (23), (22), (9), (9), (8), (7), (6), (6), (5), (4), (3), (1), (1), (1), (1), (1)
Applications (242), (100), (80), (78), (63), (17), (17), (15), (12), (11), (10), (6), (4), (3), (2), (2), (2), (1)
Conjugates (11), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (31), (19), (13), (13), (8), (8), (7), (5), (4), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)