anti-Flotillin 2 antibody (FLOT2) (AA 122-379)

Details for Product anti-FLOT2 Antibody No. ABIN967932
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Antigen
Synonyms CG11547, CG14409, CG32593, DmFlo2, Dmel\\CG32593, FLO2, FLO[Dm]-2, Flo2, flo2, reggie-1, ecs-1, ecs1, esa, esa1, flotillin-2, FLOT2, ECS-1, ECS1, ESA, ESA1, M17S1, AI573412, Esa, reggie-2, MVCD5, PON
Epitope
AA 122-379
(18), (4), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(69), (24), (24), (4), (4), (1), (1), (1)
Host
Mouse
(39), (18), (17)
Clonality (Clone)
Monoclonal ()
Conjugate
This Flotillin 2 antibody is un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
(56), (25), (20), (10), (7), (5), (5), (4), (3), (3), (1), (1), (1)
Pubmed 5 references available
Quantity 50 μg
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Immunogen Human ESA
Clone OPG-01
Isotype IgG1
Cross-Reactivity Dog (Canine), Rat (Rattus), Mouse (Murine), Chicken
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Flotillin-2 (FLOT2 Antibody Abstract)
Background Flotillin-2/ESA (epidermal surface antigen) plays a role in intercellular epidermal adhesion. Epidermal surface proteins have an important role in normal epidermal maintenance and function. In addition, they are involved in various autoimmune diseases in which auto-antibodies bind to normal epidermal cell surface proteins. This binding causes cell disadherence that leads to blister formation. Such antibodies have been utilized to identify new proteins involved in epidermal cell adhesion. One of these antibodies, ECS-1, was used to isolate Flotillin-2/ESA. The single copy ESA gene is located on the long arm of human chromosome 17, in the region containing the gene for neurofibromatosis 1 (NF1). ESA mRNA is expressed in cultured keratinocytes, melanocytes, fibroblasts, and carcinoma and melanoma cell lines. Flotillin-2/ESA may play a critical role in epidermal structure and maintenance.
Synonyms: ESA
Molecular Weight 42 kDa
Comment

Related Products: ABIN968536, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Flotillin 2 (FLOT2) (AA 122-379) antibody Western blot analysis of Flotillin-2 on human endothelial cell lysate. Lane 1: 1:5000...
anti-Flotillin 2 (FLOT2) (AA 122-379) antibody (2) Immunofluorescent staining of WI38 cells.
Product cited in: Nebl, Pestonjamasp, Leszyk et al.: "Proteomic analysis of a detergent-resistant membrane skeleton from neutrophil plasma membranes." in: The Journal of biological chemistry, Vol. 277, Issue 45, pp. 43399-409, 2002 (PubMed).

Salzer, Hinterdorfer, Hunger et al.: "Ca(++)-dependent vesicle release from erythrocytes involves stomatin-specific lipid rafts, synexin (annexin VII), and sorcin." in: Blood, Vol. 99, Issue 7, pp. 2569-77, 2002 (PubMed).

Stuermer, Lang, Kirsch et al.: "Glycosylphosphatidyl inositol-anchored proteins and fyn kinase assemble in noncaveolar plasma membrane microdomains defined by reggie-1 and -2." in: Molecular biology of the cell, Vol. 12, Issue 10, pp. 3031-45, 2001 (PubMed).

Rybin, Xu, Lisanti et al.: "Differential targeting of beta -adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae. A mechanism to functionally regulate the cAMP signaling pathway." in: The Journal of biological chemistry, Vol. 275, Issue 52, pp. 41447-57, 2001 (PubMed).

Schroeder, Stewart-Galetka, Mandavilli et al.: "Cloning and characterization of a novel epidermal cell surface antigen (ESA)." in: The Journal of biological chemistry, Vol. 269, Issue 31, pp. 19983-91, 1994 (PubMed).

Validation Images
Catalog No. ABIN967932
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