anti-E-cadherin antibody (Cadherin 1, Type 1, E-Cadherin (Epithelial)) (AA 735-883)

Details for Product anti-CDH1 Antibody No. ABIN967948
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Antigen
Synonyms
E-Cad, E-cadherin, XB-cadherin, XBcad, XTCAD-1, b-cadherin, cadherin-1, cdh1-a, cdhc-A, cdhp, hjmd, l-cam, lcam, pcad, uvo, uvomorulin, xb-cad, xcdh1, Arc1, AA960649, E-cad, Ecad, L-CAM, UVO, Um, Arc- ... show more
E-Cad, E-cadherin, XB-cadherin, XBcad, XTCAD-1, b-cadherin, cadherin-1, cdh1-a, cdhc-A, cdhp, hjmd, l-cam, lcam, pcad, uvo, uvomorulin, xb-cad, xcdh1, Arc1, AA960649, E-cad, Ecad, L-CAM, UVO, Um, Arc-1, CD324, CDHE, ECAD, LCAM, arc-1, cd324, cdhe, ecad, cdh1, si:dz180o5.2 show less
Epitope
AA 735-883
(36), (27), (25), (19), (14), (14), (14), (13), (11), (8), (7), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(358), (103), (81), (14), (10), (5), (5), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Host
Mouse
(232), (147), (13), (9), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
This E-cadherin antibody is un-conjugated
(17), (16), (13), (11), (10), (7), (5), (3), (3), (3), (3), (3), (3), (3), (1)
Application
Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)
(294), (120), (98), (87), (84), (59), (54), (49), (36), (30), (10), (8), (3), (2), (2), (1), (1), (1), (1), (1)
Pubmed 5 references available
Quantity 50 μg
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Immunogen Human E-Cadherin
Clone L10CC10
Isotype IgG2b
Cross-Reactivity Dog (Canine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name E-Cadherin (CDH1 Antibody Abstract)
Background E-Cadherin is a 120kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with cortical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression. This antibody is routinely tested by western blot analysis.
Molecular Weight 120 kDa
Comment

Related Products: ABIN967389, ABIN968533

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) (AA 735-883) antibody Western blot analysis of E-Cadherin on A431 cell lysate. Lane 1: 1:250, lane 2: 1:500...
anti-Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) (AA 735-883) antibody (2) Immunofluorescent staining of Human Fibroblasts with anti-E-Cadherin antibody.
Product cited in: Zundel, Swiersz, Giaccia: "Caveolin 1-mediated regulation of receptor tyrosine kinase-associated phosphatidylinositol 3-kinase activity by ceramide." in: Molecular and cellular biology, Vol. 20, Issue 5, pp. 1507-14, 2000 (PubMed).

Huan, van Adelsberg: "Polycystin-1, the PKD1 gene product, is in a complex containing E-cadherin and the catenins." in: The Journal of clinical investigation, Vol. 104, Issue 10, pp. 1459-68, 1999 (PubMed).

Chitaev, Troyanovsky: "Adhesive but not lateral E-cadherin complexes require calcium and catenins for their formation." in: The Journal of cell biology, Vol. 142, Issue 3, pp. 837-46, 1998 (PubMed).

Behrens, Vakaet, Friis et al.: "Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene." in: The Journal of cell biology, Vol. 120, Issue 3, pp. 757-66, 1993 (PubMed).

Takeichi: "The cadherins: cell-cell adhesion molecules controlling animal morphogenesis." in: Development (Cambridge, England), Vol. 102, Issue 4, pp. 639-55, 1988 (PubMed).

Validation Images
Catalog No. ABIN967948
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