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SNAP91 antibody (AA 706-896)

SNAP91 Reactivity: Human, Rat, Mouse WB, IHC, IF, IP Host: Mouse Monoclonal 34-AP180 unconjugated
Catalog No. ABIN967993
  • Target See all SNAP91 Antibodies
    SNAP91 (Synaptosomal-Associated Protein 91 (SNAP91))
    Binding Specificity
    • 15
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 706-896
    Reactivity
    • 18
    • 15
    • 4
    • 1
    Human, Rat, Mouse
    Host
    • 29
    • 3
    Mouse
    Clonality
    • 32
    Monoclonal
    Conjugate
    • 11
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SNAP91 antibody is un-conjugated
    Application
    • 22
    • 13
    • 13
    • 7
    • 4
    • 3
    • 3
    • 2
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
    Cross-Reactivity
    Mouse (Murine), Human
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Rat AP180 aa. 706-896
    Clone
    34-AP180
    Isotype
    IgG1
    Top Product
    Discover our top product SNAP91 Primary Antibody
  • Comment

    Related Products: ABIN968545, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20° C.
  • Kalthoff, Groos, Kohl, Mahrhold, Ungewickell: "Clint: a novel clathrin-binding ENTH-domain protein at the Golgi." in: Molecular biology of the cell, Vol. 13, Issue 11, pp. 4060-73, (2002) (PubMed).

    Drake, Traub: "Interaction of two structurally distinct sequence types with the clathrin terminal domain beta-propeller." in: The Journal of biological chemistry, Vol. 276, Issue 31, pp. 28700-9, (2001) (PubMed).

    Traub, Downs, Westrich, Fremont: "Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 16, pp. 8907-12, (1999) (PubMed).

    Ye, Lafer: "Clathrin binding and assembly activities of expressed domains of the synapse-specific clathrin assembly protein AP-3." in: The Journal of biological chemistry, Vol. 270, Issue 18, pp. 10933-9, (1995) (PubMed).

    Morris, Schröder, Plessmann, Weber, Ungewickell: "Clathrin assembly protein AP180: primary structure, domain organization and identification of a clathrin binding site." in: The EMBO journal, Vol. 12, Issue 2, pp. 667-75, (1993) (PubMed).

  • Target
    SNAP91 (Synaptosomal-Associated Protein 91 (SNAP91))
    Alternative Name
    AP180 (SNAP91 Products)
    Synonyms
    AP180 antibody, CALM antibody, Ap180 antibody, 91kDa antibody, F1-20 antibody, mKIAA0656 antibody, synaptosome associated protein 91 antibody, synaptosomal-associated protein, 91kDa homolog antibody, synaptosomal-associated protein 91 antibody, SNAP91 antibody, LOC100147907 antibody, Snap91 antibody
    Background
    AP180, also known as AP-3, F1-20, NP185, and pp155, is one of four assembly proteins which are involved in the organization and assembly of clathrin triskelia in clathrin-coated vesicles. Two of these proteins, AP-1 and AP-2, exist as tetramers, while AP180 and auxilin are monomeric assembly proteins. The clathrin binding potential of AP180 is defined by several regions of the molecule, including the 30 kDa N-terminal domain, a central domain, and a 58 kDa C-terminal domain. Although clathrin binding occurs throughout the molecule, only the C-terminal domain is associated with both binding of clathrin and assembly of clathrin cages. The highly acidic central domain, which contains an uncharged alanine-rich segment, is thought to impart the irregular physical properties to this protein. AP180 is the only clathrin assembly protein specific for synapses and is thought to be involved in synaptic vesicle biogenesis and recycling. Furthermore, AP180 is bound by inositol-6-phosphate which has been shown to be closely regulated in neuronal cells by external stimuli.
    Synonyms: AP-3, F1-20, NP185, and pp155
    Molecular Weight
    180 kDa
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