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Details for Product No. ABIN967993

Synaptosomal-Associated Protein, 91kDa Homolog (Mouse) (SNAP91) (AA 706-896) antibody

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Antigen
Synonyms AP180, CALM, Ap180, 91kDa, F1-20, mKIAA0656
Epitope
»Alternatives AA 706-896
Reactivity
»Alternatives Rat (Rattus)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (IHC)
Pubmed 5 references available
Catalog no. ABIN967993
Quantity 50 µg
Price
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Immunogen Rat AP180
Clone L10CC10
Isotype IgG1
Cross-Reactivity Mouse (Murine), Human
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name AP180
Background AP180, also known as AP-3, F1-20, NP185, and pp155, is one of four assembly proteins which are involved in the organization and assembly of clathrin triskelia in clathrin-coated vesicles. Two of these proteins, AP-1 and AP-2, exist as tetramers, while AP180 and auxilin are monomeric assembly proteins. The clathrin binding potential of AP180 is defined by several regions of the molecule, including the 30 kDa N-terminal domain, a central domain, and a 58 kDa C-terminal domain. Although clathrin binding occurs throughout the molecule, only the C-terminal domain is associated with both binding of clathrin and assembly of clathrin cages. The highly acidic central domain, which contains an uncharged alanine-rich segment, is thought to impart the irregular physical properties to this protein. AP180 is the only clathrin assembly protein specific for synapses and is thought to be involved in synaptic vesicle biogenesis and recycling. Furthermore, AP180 is bound by inositol-6-phosphate which has been shown to be closely regulated in neuronal cells by external stimuli.
Synonyms: AP-3, F1-20, NP185, and pp155
Molecular Weight 180 kDa
Research Area Neurology
Comment

Related Products: ABIN968545, ABIN967389

Restrictions For Research Use only
Format Liquid
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Ye, Lafer: "Clathrin binding and assembly activities of expressed domains of the synapse-specific clathrin assembly protein AP-3." in: The Journal of biological chemistry, Vol. 270, Issue 18, pp. 10933-9, 1995 (PubMed).

Morris, Schröder, Plessmann et al.: "Clathrin assembly protein AP180: primary structure, domain organization and identification of a clathrin binding site." in: The EMBO journal, Vol. 12, Issue 2, pp. 667-75, 1993 (PubMed).

Traub, Downs, Westrich et al.: "Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 16, pp. 8907-12, 1999 (PubMed).

Drake, Traub: "Interaction of two structurally distinct sequence types with the clathrin terminal domain beta-propeller." in: The Journal of biological chemistry, Vol. 276, Issue 31, pp. 28700-9, 2001 (PubMed).

Kalthoff, Groos, Kohl et al.: "Clint: a novel clathrin-binding ENTH-domain protein at the Golgi." in: Molecular biology of the cell, Vol. 13, Issue 11, pp. 4060-73, 2002 (PubMed).

Alternatives for antigen "Synaptosomal-Associated Protein, 91kDa Homolog (Mouse) (SNAP91)", type "Antibodies"
Hosts (15), (6)
Reactivities (20), (17), (16), (14), (13), (12), (12)
Applications (12), (10), (4), (4), (3), (2), (2), (2), (2)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (2), (1), (1)
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