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Syntaxin 6 (STX6) (AA 6-136) antibody

Details for Product No. ABIN968079, Supplier: Log in to see
Antigen
  • CG7736
  • CT23545
  • Dm Syx6
  • DmSyx6
  • Dmel\\CG7736
  • SYN6
  • SYX6/10
  • Syx
  • MGC78971
  • MGC132090
  • STX6
  • fb51b08
  • wu:fb51b08
  • zgc:110658
  • si:dkey-121a11.2
  • LOC734102
  • Syx6
  • Bmsyx6
  • Syntaxin-6
  • 2310039E05Rik
  • 2410005I16Rik
  • AA437559
  • AI415714
  • AI845861
Epitope
AA 6-136
25
16
11
2
2
2
2
1
1
1
1
1
1
Reactivity
Chicken, Dog (Canine), Frog, Human, Mouse (Murine), Rat (Rattus)
81
29
26
17
4
3
2
1
1
1
1
Host
Mouse
72
16
12
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
12
12
11
3
3
3
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
80
57
12
11
10
9
5
2
1
Supplier
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Immunogen Rat Syntaxin 6 aa. 6-136
Clone 30-Syntaxin 6
Isotype IgG1
Cross-Reactivity Human, Mouse (Murine), Dog (Canine), Chicken, Frog
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Syntaxin 6 (STX6 Antibody Abstract)
Background Signal transmission between cells is often regulated by the secretion of neurotransmitters or hormones into the extracellular space. This process is controlled by a complex pathway of membrane trafficking which leads to membrane fusion and secretion. Syntaxin 1 is involved in three important complexes that modulate the secretion process: syntaxin and n-sec-1, syntaxin, VAMP, and SNAP-25, and syntaxin, VAMP, SNAP-25, alphaSNAP, and NSF (20S complex). Syntaxin 6 is a 255 amino acid member of the syntaxin family. It contains a C-terminal transmembrane domain and is located at the Golgi apparatus. In addition, Syntaxin 6 displays significant (47% identity) homology with SNAP-25. In vitro, Syntaxin 6 has been reported to interact with alpha-SNAP. Syntaxin 6 has been reported to have a calculated molecular weight of 30.6 kDa, but has been observed to migrate in a range inbetween ~ 31-35 kDa.
Molecular Weight 31-35 kDa
Research Area Signaling
Pathways
Comment

Related Products: ABIN968533, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-Syntaxin 6 (STX6) (AA 6-136) antibody (ABIN968079) Western blot analysis of Syntaxin 6 on a A431 cell lysate (Human epithelial carcinoma...
Immunofluorescence (IF) image for anti-Syntaxin 6 (STX6) (AA 6-136) antibody (ABIN968079) Immunofluorescence staining of PSFK-1 cells (Human neuroectodermal tumor line, ATCC C...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Syntaxin 6 (STX6) (AA 6-136) antibody (ABIN968079) Immunohistochemical staining on a rat brain section for Syntaxin 6. A formalin-fixed ...
Product cited in: Shewan, van Dam, Martin et al.: "GLUT4 recycles via a trans-Golgi network (TGN) subdomain enriched in Syntaxins 6 and 16 but not TGN38: involvement of an acidic targeting motif." in: Molecular biology of the cell, Vol. 14, Issue 3, pp. 973-86, 2003 (PubMed).

Ramalho-Santos, Moreno, Sutovsky et al.: "SNAREs in mammalian sperm: possible implications for fertilization." in: Developmental biology, Vol. 223, Issue 1, pp. 54-69, 2000 (PubMed).

Background publications Mullock, Smith, Ihrke et al.: "Syntaxin 7 is localized to late endosome compartments, associates with Vamp 8, and Is required for late endosome-lysosome fusion." in: Molecular biology of the cell, Vol. 11, Issue 9, pp. 3137-53, 2000 (PubMed).

Bock, Lin, Scheller: "A new syntaxin family member implicated in targeting of intracellular transport vesicles." in: The Journal of biological chemistry, Vol. 271, Issue 30, pp. 17961-5, 1996 (PubMed).