Small Nuclear Ribonucleoprotein N (SNRPN) (AA 14-174) antibody

Details for Product No. ABIN968086
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Epitope
AA 14-174
Reactivity
Human
Host
Mouse
Clonality (Clone)
Monoclonal ()
Application
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
Pubmed 5 references available
Catalog no. ABIN968086
Quantity 150 µg
Price
Contact our Customer Service for availability and price in your country.
Options
Shipping to United States (Change)
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Human SMN
Clone 8
Isotype IgG1
Cross-Reactivity Mouse (Murine), Rat (Rattus), Dog (Canine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name SMN
Background SMN (survival motor neuron) was discovered as a candidate gene, located in chromosome 5q13, for the fatal autosomal Spinal muscular atrophy (SMA) disorder. The SMN gene was missing or interrupted in a significant number of patients with SMA. The SMN protein is 294 amino acids and migrates with apparent molecular weight of 40 kDa. In addition to the cytoplasm, other studies localized SMN in dots of 0.1-1.0 µm within the nucleus. These novel nuclear structures were named gems and found associated to coiled bodies. It was also found that SMN interacts with the RGG box of hnRNP U and fibrillarin. Therefore, the biochemical function of SMN may be in the regulation of mRNA metabolism.
Synonyms: Survival Motor Neuron
Molecular Weight 40 kDa
Comment

Related Products: ABIN968587, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Supplier Images
anti-Small Nuclear Ribonucleoprotein N (SNRPN) (AA 14-174) antibody Western blot analysis of SMN on a HepG2 cell lysate (Human hepatocellular carcinoma, ATCC HB-8065). Lane 1: 1:5000, lane 2: 1:10,000, lane 3: 1:20,000 dilution of the mouse anti-SMN antibody.
anti-Small Nuclear Ribonucleoprotein N (SNRPN) (AA 14-174) antibody (2) Immunofluorescence staining of HeLa cells (Human cervical epitheloid carcinoma, ATCC CCL-2.2).
anti-Small Nuclear Ribonucleoprotein N (SNRPN) (AA 14-174) antibody (3) Immunohistochemical staining of pyrimidal cells in a rat cortex, formalin-fixed paraffin-embedded tissue section, with citrate pre-treatment (magnification, 20X).
Product cited in: Lefebvre, Bürglen, Reboullet et al.: "Identification and characterization of a spinal muscular atrophy-determining gene." in: Cell, Vol. 80, Issue 1, pp. 155-65, 1995 (PubMed).

Cifuentes-Diaz, Frugier, Tiziano et al.: "Deletion of murine SMN exon 7 directed to skeletal muscle leads to severe muscular dystrophy." in: The Journal of cell biology, Vol. 152, Issue 5, pp. 1107-14, 2001 (PubMed).

Wang, Reddy, Shen: "Higher order arrangement of the eukaryotic nuclear bodies." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 21, pp. 13583-8, 2002 (PubMed).

Claus, Doring, Gringel et al.: "Differential intranuclear localization of fibroblast growth factor-2 isoforms and specific interaction with the survival of motoneuron protein." in: The Journal of biological chemistry, Vol. 278, Issue 1, pp. 479-85, 2002 (PubMed).

Côté, Boisvert, Boulanger et al.: "Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1." in: Molecular biology of the cell, Vol. 14, Issue 1, pp. 274-87, 2003 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
back to top