N-Acetyltransferase 1 (Arylamine N-Acetyltransferase) (NAT1) (AA 672-830) antibody

Details for Product No. ABIN968148
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Antigen
Synonyms Nat, AAC1, MNAT, NAT-1, NATI, Nat-1, NAT1, DRCF-6, Eif4g2
Epitope
AA 672-830
(3), (2), (1), (1)
Reactivity
Human
(20), (6), (6)
Host
Mouse
(16), (2), (2)
Clonality (Clone)
Monoclonal ()
Application
Western Blotting (WB), Immunofluorescence (IF)
(17), (10), (8), (3), (2)
Pubmed 3 references available
Catalog no. ABIN968148
Quantity 50 µg
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Immunogen Human NAT1
Clone G52C7-1
Isotype IgG1
Cross-Reactivity Mouse (Murine), Rat (Rattus), Dog (Canine), Cow (Bovine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name NAT1
Background EIF-4 proteins are required for recognition of mRNA and acceleration of protein translation. This group of proteins consists of the RNA helicase eIF-4A, the RNA-binding protein eIF-4B, the cap-binding protein eIF-4E, and eIF-4G (p220). NAT1 (Novel APOBEC-1 Target no. 1), also known as DAP-5 (Death Associated Protein -5), is homologous to eIF-4G. Amino acid sequence comparison of NAT1 and eIF-4 shows that NAT1 lacks an eIF-4G N-terminal region. This region mediates eIF-4G association with eIF-4E. The highest degree of homology is within the central portions of NAT1 and eIF-4G, while the lowest degree of homology occurs at the C-terminus. NAT1 more closely resembles a cleaved form of eIF-4G that is involved in cap-independent translation. It is thought that NAT1 is involved in the repression of translation via its inhibition of both cap-dependent and cap-independent translation.
Synonyms: Novel APOBEC-1 Target no. 1, DAP-5, Death Associated Protein -5
Molecular Weight 100 kDa
Research Area Signaling, Metabolism, Amino Acids
Comment

Related Products: ABIN968535, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Supplier Images
anti-N-Acetyltransferase 1 (Arylamine N-Acetyltransferase) (NAT1) (AA 672-830) antibody Western blot analysis of NAT1 on a HeLa cell lysate (Human cervical epitheloid carcinoma, ATCC CCL-2). Lane 1: 1:500, lane 2: 1:1000, lane 3: 1:2000 dilution of the mouse anti-NAT1 antibody.
anti-N-Acetyltransferase 1 (Arylamine N-Acetyltransferase) (NAT1) (AA 672-830) antibody (2) Immunofluorescence staining of mouse macrophages.
Product cited in: Yamanaka, Poksay, Arnold et al.: "A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme." in: Genes & development, Vol. 11, Issue 3, pp. 321-33, 1997 (PubMed).

Levy-Strumpf, Deiss, Berissi et al.: "DAP-5, a novel homolog of eukaryotic translation initiation factor 4G isolated as a putative modulator of gamma interferon-induced programmed cell death." in: Molecular and cellular biology, Vol. 17, Issue 3, pp. 1615-25, 1997 (PubMed).

Henis-Korenblit, Strumpf, Goldstaub et al.: "A novel form of DAP5 protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site-mediated translation." in: Molecular and cellular biology, Vol. 20, Issue 2, pp. 496-506, 2000 (PubMed).

Hosts (16), (2), (2)
Reactivities (20), (6), (6)
Applications (17), (10), (8), (3), (2)
Epitopes (3), (2), (1), (1)
Request Want additional data for this product?

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Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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