Scavenger Receptor Class B, Member 1 (SCARB1) (AA 104-294) antibody

Antigen: Scavenger Receptor Class B, Member 1 (SCARB1)

Synonyms: CLA1, SRB1, CLA-1, SR-BI, CD36L1, MGC138242, CD36, Cla1, SRBI, Srb1, Cla-1, SR-B1, Cd36l1, mSR-BI, AI120173, D5Ertd460e, SCARB1, cb1015, Scarb1

Binding Site: AA 104-294

Clonality: Monoclonal (25)

Host: Mouse

Reactivity: Human

Application: Western Blotting (WB), Immunofluorescence (IF)

Catalog no.: ABIN968230

Additional Information

Alternative name: CLA-1

Immunogen: Human CLA-1

Format: Liquid

Isotype: IgG1, kappa

Clone: 25

Description: CLA-1 (CD36 and LIMPII Analogous-1) is member of a novel gene family that includes CD36, LIMPII, and SR-BI. CD36 is a cell surface glycoprotein that binds to collagen type I and thrombospondin. LIMPII (lysosomal integral membrane protein II), as its name suggests, is expressed on the membrane of lysosomes. SR-BI (scavenger receptor type B class I) is involved in the selective uptake of cholesterol esters. These proteins include two membrane-anchoring regions, two short cytoplasmic tails, and a large extracellular/luminal domain. CLA-1 mRNA is detected in a wide range of tissues including adrenal glands, liver, and testis. Its expression and similarity with other family members suggest it may play a role in HDL metabolism. However, identification of the CLA-1 receptor on monocytes indicates additional CLA-1 functions in leukocytes.
Synonyms: CD36 and LIMPII Analogous-1

Characteristics: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Molecular Weight: 80 kDa

Comments:

Related Products: ABIN968535, ABIN967389

Application Details

Concentration: 250 µg/ml

Purity: Purified

Purification: Purified from tissue culture supernatant or ascites by affinity chromatography.

Buffer: Aqueous buffered solution containing BSA, glycerol.

Preservative: 0.09% Sodium azide.

Storage: Store undiluted at -20°C.

Restrictions: For Research Use only

Images

Western blot analysis of CLA-1 on a HeLa cell lysate (Human cervical epitheloid carcinoma, ATCC CCL-2.2). Lane 1: 1: 500, lane 2: 1:1000, lane 3: 1:2000 dilution of the mouse anti-human CLA-1 antibody.

Immunofluorescence staining of human endothelial cells.

Publications

Product: Calvo, Vega: "Identification, primary structure, and distribution of CLA-1, a novel member of the CD36/LIMPII gene family." in: The Journal of biological chemistry, Vol. 268, Issue 25, pp. 18929-35, 1993 (PubMed).

Acton, Rigotti, Landschulz et al.: "Identification of scavenger receptor SR-BI as a high density lipoprotein receptor." in: Science (New York, N.Y.), Vol. 271, Issue 5248, pp. 518-20, 1996 (PubMed).

Kozarsky, Donahee, Rigotti et al.: "Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels." in: Nature, Vol. 387, Issue 6631, pp. 414-7, 1997 (PubMed).

Lasley, Narayan, Uittenbogaard et al.: "Activated cardiac adenosine A(1) receptors translocate out of caveolae." in: The Journal of biological chemistry, Vol. 275, Issue 6, pp. 4417-21, 2000 (PubMed).