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BCAN antibody (AA 232-394)

BCAN Reactivity: Rat, Mouse, Dog WB, IF Host: Mouse Monoclonal 2-Brevican unconjugated
Catalog No. ABIN968236
  • Target See all BCAN Antibodies
    BCAN (Brevican (BCAN))
    Binding Specificity
    • 14
    • 8
    • 7
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 232-394
    Reactivity
    • 32
    • 19
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Rat, Mouse, Dog
    Host
    • 26
    • 21
    • 2
    Mouse
    Clonality
    • 30
    • 19
    Monoclonal
    Conjugate
    • 20
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This BCAN antibody is un-conjugated
    Application
    • 39
    • 20
    • 17
    • 17
    • 14
    • 13
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Cross-Reactivity
    Mouse (Murine), Dog (Canine)
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Rat Brevican aa. 232-394
    Clone
    2-Brevican
    Isotype
    IgG1
    Top Product
    Discover our top product BCAN Primary Antibody
  • Comment

    Related Products: ABIN968545, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20° C.
  • Aspberg, Miura, Bourdoulous, Shimonaka, Heinegârd, Schachner, Ruoslahti, Yamaguchi: "The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 19, pp. 10116-21, (1997) (PubMed).

    Seidenbecher, Richter, Rauch, Fässler, Garner, Gundelfinger: "Brevican, a chondroitin sulfate proteoglycan of rat brain, occurs as secreted and cell surface glycosylphosphatidylinositol-anchored isoforms." in: The Journal of biological chemistry, Vol. 270, Issue 45, pp. 27206-12, (1995) (PubMed).

    Yamada, Watanabe, Shimonaka, Yamaguchi: "Molecular cloning of brevican, a novel brain proteoglycan of the aggrecan/versican family." in: The Journal of biological chemistry, Vol. 269, Issue 13, pp. 10119-26, (1994) (PubMed).

  • Target
    BCAN (Brevican (BCAN))
    Alternative Name
    Brevican (BCAN Products)
    Synonyms
    fi32a12 antibody, wu:fi32a12 antibody, BCAN antibody, Xbcan antibody, Cspg7 antibody, ALPBRE antibody, BEHAB antibody, CSPG7 antibody, brevican antibody, brevican L homeolog antibody, bcan antibody, BCAN antibody, bcan.L antibody, Bcan antibody
    Background
    Neural tissue expresses a variety of cell surface heparan sulfate and extracellular chondroitin sulfate containing proteoglycans. Brevican, a chondroitin sulfate proteoglycan, is a member of the lectican family. Other members of this family are aggrecan, versican, and neurocan. These proteins are either heparan sulfate or keratan sulfate containing glycosylphosphatidylinositol (GPI) anchored or membrane spanning proteoglycans, or soluble chondroitin sulfate containing proteoglycans. Brevican exists as either a soluble or GPI-anchored plasma membrane protein. Brevican contains the shortest core protein of any of the family members. In addition, it is characterized by chondroitin sulfate chains, an N-terminal hyaluronic acid-binding domain (HA), an epidermal growth factor-like (EGF) repeat, and lectin-like and complement regulatory protein-like domains in its C-terminal region. Primary cerebellar astrocytes are the major site for mRNA expression and little, if any, is found in neurons. Although there is an 80 kDa N-terminal truncated form, full length brevican can be up to 145 kDa. Brevican is thought to play a role in the terminal differentiation and regulation of the adult nervous system. This antibody is routinely tested by western blot analysis.
    Molecular Weight
    140-145 kDa
    Pathways
    Glycosaminoglycan Metabolic Process
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