Thymopoietin (TMPO) (AA 34-156) antibody

Details for Product No. ABIN968307
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms LAP2, CMD1T, LEMD4, PRO0868, TP, lap2, LAP2beta, 5630400D24Rik, AI195756, AI606875, AW214352, AW547477, tmpo, wu:fc26f12, wu:fd21f02, wu:fi29h05
Epitope
AA 34-156
(20), (8), (7), (7), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Rat (Rattus)
(46), (17), (13), (3), (3), (2), (2), (1)
Host
Mouse
(41), (6), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB), Immunofluorescence (IF)
(49), (21), (13), (8), (4), (3), (2), (2)
Pubmed 5 references available
Quantity 50 μg
Options
Shipping to United States (Change)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN968307
Contact our Customer Service for availability and price in your country.
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Rat LAP2
Clone MK-1-410
Isotype IgG1
Cross-Reactivity Mouse (Murine), Human, Dog (Canine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name LAP2
Background A specialized extension of the ER, the nuclear envelope (NE) forms the nuclear compartment boundary in eukaryotic cells. It contains numerous pore complexes and the nucleoplasmic side is linked to nuclear lamina. The nuclear lamina composes the structural framework for the NE and serves as a chromatin anchor site, thus, playing a major role in interphase nuclear organization. Many proteins are associated with lamina, particularly the LAPs (Lamina-Associated Polypeptides). LAP2 (also known as LAP2beta) is a hydrophilic protein with a single transmembrane segment near the C-terminus. Thus, it has been defined as a type II integral membrane protein with the majority of its structure exposed to the nucleoplasm. LAP2 binding to lamins contributes to the attachment of the nuclear lamina to the inner nuclear membrane. LAP2 also binds to chromatin, implying its role in chromosomal organization during mitosis. Mitotic phosphorylation of LAP2 regulates its binding to lamins and chromosomes during the disassembly and reassembly of mitosis. Thus, LAP2 is a nuclear protein that plays a role in the organization of the NE during cell cycle progression.
Synonyms: LAP2beta, Lamina-Associated Polypeptides
Molecular Weight 53 kDa
Research Area Signaling, Cytoskeleton
Comment

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Thymopoietin (TMPO) (AA 34-156) antibody Immunofluorescence staining of HeLa cells (Human cervical epitheloid carcinoma, ATCC CCL-2.2).
anti-Thymopoietin (TMPO) (AA 34-156) antibody (2) Western blot analysis of LAP2 on a RSV-3T3 cell lysate. Lane 1: 1:5000, lane 2: 1:10,000, lane 3: 1:20,000 dilution of the mouse anti-LAP2 antibody.
anti-Thymopoietin (TMPO) (AA 34-156) antibody (3) anti-Thymopoietin (TMPO) (AA 34-156) antibody (Image 3)
Product cited in: Furukawa, Panté, Aebi et al.: "Cloning of a cDNA for lamina-associated polypeptide 2 (LAP2) and identification of regions that specify targeting to the nuclear envelope." in: The EMBO journal, Vol. 14, Issue 8, pp. 1626-36, 1995 (PubMed).

Furukawa, Fritze, Gerace: "The major nuclear envelope targeting domain of LAP2 coincides with its lamin binding region but is distinct from its chromatin interaction domain." in: The Journal of biological chemistry, Vol. 273, Issue 7, pp. 4213-9, 1998 (PubMed).

Dechat, Gotzmann, Stockinger et al.: "Detergent-salt resistance of LAP2alpha in interphase nuclei and phosphorylation-dependent association with chromosomes early in nuclear assembly implies functions in nuclear structure dynamics." in: The EMBO journal, Vol. 17, Issue 16, pp. 4887-902, 1998 (PubMed).

Rusan, Tulu, Fagerstrom et al.: "Reorganization of the microtubule array in prophase/prometaphase requires cytoplasmic dynein-dependent microtubule transport." in: The Journal of cell biology, Vol. 158, Issue 6, pp. 997-1003, 2002 (PubMed).

Kimura, Ito, Watanabe et al.: "Mouse germ cell-less as an essential component for nuclear integrity." in: Molecular and cellular biology, Vol. 23, Issue 4, pp. 1304-15, 2003 (PubMed).

Validation Images
Did you look for something else?
back to top