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PP5 antibody (AA 36-238)

PPP5C Reactivity: Human, Rat, Mouse, Dog WB, IF Host: Mouse Monoclonal 3-PP5 unconjugated
Catalog No. ABIN968321
  • Target See all PP5 (PPP5C) Antibodies
    PP5 (PPP5C) (Protein Phosphatase 5, Catalytic Subunit (PPP5C))
    Binding Specificity
    • 11
    • 8
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 36-238
    Reactivity
    • 75
    • 12
    • 11
    • 7
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    Human, Rat, Mouse, Dog
    Host
    • 41
    • 34
    Mouse
    Clonality
    • 43
    • 32
    Monoclonal
    Conjugate
    • 36
    • 5
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PP5 antibody is un-conjugated
    Application
    • 65
    • 31
    • 27
    • 23
    • 22
    • 11
    • 5
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Cross-Reactivity
    Mouse (Murine), Human, Dog (Canine)
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Rat PP5 aa. 36-238
    Clone
    3-PP5
    Isotype
    IgG1
    Top Product
    Discover our top product PPP5C Primary Antibody
  • Comment

    Related Products: ABIN968545, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20° C.
  • Das, Cohen, Barford: "The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions." in: The EMBO journal, Vol. 17, Issue 5, pp. 1192-9, (1998) (PubMed).

    Ollendorff, Donoghue: "The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex." in: The Journal of biological chemistry, Vol. 272, Issue 51, pp. 32011-8, (1998) (PubMed).

    Zuo, Dean, Honkanen: "Serine/threonine protein phosphatase type 5 acts upstream of p53 to regulate the induction of p21(WAF1/Cip1) and mediate growth arrest." in: The Journal of biological chemistry, Vol. 273, Issue 20, pp. 12250-8, (1998) (PubMed).

    Becker, Kentrup, Klumpp, Schultz, Joost: "Molecular cloning of a protein serine/threonine phosphatase containing a putative regulatory tetratricopeptide repeat domain." in: The Journal of biological chemistry, Vol. 269, Issue 36, pp. 22586-92, (1994) (PubMed).

    Chen, McPartlin, Brown, Chen, Barker, Cohen: "A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus." in: The EMBO journal, Vol. 13, Issue 18, pp. 4278-90, (1994) (PubMed).

  • Target
    PP5 (PPP5C) (Protein Phosphatase 5, Catalytic Subunit (PPP5C))
    Alternative Name
    PP5 (PPP5C Products)
    Synonyms
    PP5 antibody, PPP5 antibody, PPT antibody, AU020526 antibody, pp5 antibody, MGC89961 antibody, fc83f08 antibody, im:7146608 antibody, wu:fc83f08 antibody, zgc:110801 antibody, PPP5C antibody, protein phosphatase 5 catalytic subunit antibody, protein phosphatase 5, catalytic subunit antibody, protein phosphatase 5, catalytic subunit S homeolog antibody, serine/threonine-protein phosphatase 5 antibody, PPP5C antibody, Ppp5c antibody, ppp5c.S antibody, ppp5c antibody, LOC592155 antibody, LOC100513542 antibody, LOC100564151 antibody, LOC100186268 antibody, LOC100208775 antibody
    Background
    Phosphorylation and dephosphorylation on serine and threonine residues is critical for signal transduction and the regulation of numerous cellular functions. Phosphorylation levels are modulated by protein kinases and phosphatases. The Ser/Thr phosphatase PP5 (also known as PPT) is a model protein of the fourth subfamily of the PPP-family of phosphatases which includes PP1, PP2A, and PP2B. PP5 is primarily located in the nucleus, demonstrates widespread tissue distribution, and is highly conserved among species. It consists of a C-terminal catalytic domain and an N-terminal TPR (tetratricopeptide repeat) domain which is involved in protein-protein interactions. The TPRs of PP5 mediate protein phosphatase activity. TPRs mediate the interaction of PP5 with various proteins including the hsp90-glucocorticoid receptor complex and the kinase domain of ANP-guanylate cyclase receptor. PP5 is thought to be important in cell growth. For example, it functions upstream of p53 to regulate p21/WAF1/Cip1-mediated G1 growth arrest. Thus, PP5 is a nuclear protein phosphatase that is involved in signaling pathways of cell growth and arrest. This antibody is routinely tested by western blot analysis.
    Synonyms: PPT
    Molecular Weight
    58 kDa
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