CSRP2 antibody (AA 601-722)

Catalog No. ABIN968371

Product Details anti-CSRP2 Antibody

Target: CSRP2 (Cysteine and Glycine-Rich Protein 2 (CSRP2))

Binding Specificity: AA 601-722

Reactivity: Human, Mouse, Rat, Dog

Host: Mouse

Clonality: Monoclonal

Conjugate: This CSRP2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Cross-Reactivity: Mouse (Murine), Human, Dog (Canine)

Characteristics: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Rat DLP1 aa. 601-722

Clone: 8-DLP1

Isotype: IgG1

Application Details

Comment:

Related Products: ABIN967389, ABIN968545

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store undiluted at -20°C.

References for anti-CSRP2 antibody (ABIN968371)

Bossy, Petrilli, Klinglmayr, Chen, Lütz-Meindl, Knott, Masliah, Schwarzenbacher, Bossy-Wetzel: "S-Nitrosylation of DRP1 does not affect enzymatic activity and is not specific to Alzheimer's disease." in: Journal of Alzheimer's disease : JAD, Vol. 20 Suppl 2, Issue 6, pp. S513-26, (2010) (PubMed).

Estaquier, Arnoult: "Inhibiting Drp1-mediated mitochondrial fission selectively prevents the release of cytochrome c during apoptosis." in: Cell death and differentiation, Vol. 14, Issue 6, pp. 1086-94, (2007) (PubMed).

Karbowski, Neutzner, Youle: "The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division." in: The Journal of cell biology, Vol. 178, Issue 1, pp. 71-84, (2007) (PubMed).

Duvezin-Caubet, Jagasia, Wagener, Hofmann, Trifunovic, Hansson, Chomyn, Bauer, Attardi, Larsson, Neupert, Reichert: "Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology." in: The Journal of biological chemistry, Vol. 281, Issue 49, pp. 37972-9, (2006) (PubMed).

Jofuku, Ishihara, Mihara: "Analysis of functional domains of rat mitochondrial Fis1, the mitochondrial fission-stimulating protein." in: Biochemical and biophysical research communications, Vol. 333, Issue 2, pp. 650-9, (2005) (PubMed).

Yoon, Pitts, Dahan, McNiven: "A novel dynamin-like protein associates with cytoplasmic vesicles and tubules of the endoplasmic reticulum in mammalian cells." in: The Journal of cell biology, Vol. 140, Issue 4, pp. 779-93, (1998) (PubMed).

Target Details for CSRP2

Target: CSRP2 (Cysteine and Glycine-Rich Protein 2 (CSRP2))

Alternative Name: DLP1 (CSRP2 Products)

Synonyms: CRP2 antibody, LMO5 antibody, SmLIM antibody, crp2 antibody, lmo5 antibody, csrp1 antibody, smlim antibody, AW551867 antibody, Crp2 antibody, SmLim antibody, zgc:77740 antibody, BETA-CRP antibody, csrp2 antibody, MGC81964 antibody, CSRP2 antibody, cysteine and glycine rich protein 2 antibody, cysteine and glycine-rich protein 2 antibody, cysteine and glycine rich protein 2 L homeolog antibody, cysteine and glycine rich protein 2 S homeolog antibody, CSRP2 antibody, csrp2 antibody, Csrp2 antibody, csrp2.L antibody, csrp2.S antibody

Background: Dynamins, phosphoproteins with intrinsic GTPase activities, play an important role during early endocytosis. The GTPase activity is stimulated in vitro by microtubules, SH3 domain containing-proteins, and Protein Kinase (PKC)- mediated phosphorylation. Although highly related, dynamins are differentially expressed in an organism. For instance, dynamin I is found only in the nervous system, dynamin II is ubiquitously expressed, and dynamin III is located in lung, testis and brain. Due to four alternative splicing products for each of the dynamins, the dynamin family contains at least 12 different members. The Dynamin Like Protein-1 (DLP1) is a new member of the dynamin family of proteins. DLP1 (also known as DVLP) is widely expressed as two alternatively spliced products, each with different tissue expression patterns. The larger product is about 84 kDa and reportedly found only in the brain, whereas the 79 kDa product is ubiquitously expressed. Unlike dynamins I-III which co-localize with endocytotic vesicles, DLP1 is found aligned with microtubules and with the endoplasmic reticulum, suggesting a secretory function for this novel protein.
Synonyms: Dynamin Like Protein-1, DVLP

Molecular Weight: 79-84 kDa