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SFRS Protein Kinase 2 (SRPK2) (AA 363-485) antibody

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Synonyms srpk2, MGC147832, AW226533, AW492537, AW547358, Wbp6, mSRPK2, SFRSK2
AA 363-485
(18), (2), (2), (1), (1), (1), (1)
Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(37), (16), (13)
(35), (2)
Clonality (Clone)
Monoclonal ()
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunofluorescence (IF), Western Blotting (WB)
(24), (14), (14), (11), (8), (4), (1), (1)
Pubmed 1 reference available
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Quantity 50 μg
Shipping to United States ( )
Immunogen Human SRPK2 aa. 363-485
Clone 23-SRPK2
Isotype IgG1
Cross-Reactivity Mouse (Murine), Rat (Rattus), Dog (Canine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name SRPK2 (SRPK2 Antibody Abstract)
Background Mammalian cell pre-mRNA splicing is mediated by the spliceosome, a multi-component complex that contains two types of splicing factors: small nuclear ribonucleoprotein particles (snRNPs) and non-snRNP factors. Interactions between snRNPs and pre-mRNA ensures proper establishment of a catalytic core for the splicing reaction. However, these interactions are mediated by the non-snRNP factors. The superfamily of Arg/Ser-rich (RS) domain containing splicing factors are well known non-snRNPs. All of these proteins share a similar structure consisting of an N-terminal RNA recognition motif and a C-terminal RS domain. However, different SR factors have distinct specificities and their function is regulated by their level of expression and by reversible phosphorylation. Two families of kinases phosphorylate RS domain-containing proteins: SR protein-specific kinases (SRPK1 and 2) and Clk/Sty. SRPK1 is predominate in the pancreas, whereas SRPK2 is highly expressed in brain. SRPK2 contains an N-terminal proline-rich sequence that mediates its in vitro interaction with a WW domain containing protein. SRPKs affect splice-site selection and are thought to affect alternative splicing. This antibody is routinely tested by western blot analysis.
Synonyms: SR Protein specific Kinase-2
Molecular Weight 115 kDa
Research Area DNA/RNA, Kinases/Phosphatases

Related Products: ABIN968533, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.
Supplier Images
Western Blotting (WB) image for anti-SFRS Protein Kinase 2 (SRPK2) (AA 363-485) antibody (ABIN968376) Western blot analysis of SRPK2 on a A431 cell lysate (Human epithelial carcinoma, ATC...
Immunofluorescence (IF) image for anti-SFRS Protein Kinase 2 (SRPK2) (AA 363-485) antibody (ABIN968376) Immunofluorescence staining of MDCK cells (Canine kidney, ATCC CCL-34).
 image for anti-SFRS Protein Kinase 2 (SRPK2) (AA 363-485) antibody (ABIN968376) anti-SFRS Protein Kinase 2 (SRPK2) (AA 363-485) antibody (Image 3)
Western Blotting (WB) image for anti-SFRS Protein Kinase 2 (SRPK2) (AA 363-485) antibody (ABIN968376) anti-SFRS Protein Kinase 2 (SRPK2) (AA 363-485) antibody (Image 4)
Product cited in: Wang, Lin, Dyck et al.: "SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells." in: The Journal of cell biology, Vol. 140, Issue 4, pp. 737-50, 1998 (PubMed).

Catalog No. ABIN968376
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