SFRS Protein Kinase 2 (SRPK2) (AA 363-485) antibody

Details for Product No. ABIN968376
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Antigen
Synonyms srpk2, MGC147832, AW226533, AW492537, AW547358, Wbp6, mSRPK2, SFRSK2
Epitope
AA 363-485
(8), (2), (1), (1)
Reactivity
Human
(24), (12), (11), (11), (11), (11), (11)
Host
Mouse
(23), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF)
(14), (9), (8), (7), (6), (3), (1), (1)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN968376
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Immunogen Human SRPK2
Clone 23
Isotype IgG1
Cross-Reactivity Mouse (Murine), Rat (Rattus), Dog (Canine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name SRPK2
Background Mammalian cell pre-mRNA splicing is mediated by the spliceosome, a multi-component complex that contains two types of splicing factors: small nuclear ribonucleoprotein particles (snRNPs) and non-snRNP factors. Interactions between snRNPs and pre-mRNA ensures proper establishment of a catalytic core for the splicing reaction. However, these interactions are mediated by the non-snRNP factors. The superfamily of Arg/Ser-rich (RS) domain containing splicing factors are well known non-snRNPs. All of these proteins share a similar structure consisting of an N-terminal RNA recognition motif and a C-terminal RS domain. However, different SR factors have distinct specificities and their function is regulated by their level of expression and by reversible phosphorylation. Two families of kinases phosphorylate RS domain-containing proteins: SR protein-specific kinases (SRPK1 and 2) and Clk/Sty. SRPK1 is predominate in the pancreas, whereas SRPK2 is highly expressed in brain. SRPK2 contains an N-terminal proline-rich sequence that mediates its in vitro interaction with a WW domain containing protein. SRPKs affect splice-site selection and are thought to affect alternative splicing. This antibody is routinely tested by western blot analysis.
Synonyms: SR Protein specific Kinase-2
Molecular Weight 115 kDa
Research Area DNA/RNA, Kinases/Phosphatases
Comment

Related Products: ABIN968533, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-SFRS Protein Kinase 2 (SRPK2) (AA 363-485) antibody Immunofluorescence staining of MDCK cells (Canine kidney, ATCC CCL-34).
anti-SFRS Protein Kinase 2 (SRPK2) (AA 363-485) antibody (2) Western blot analysis of SRPK2 on a A431 cell lysate (Human epithelial carcinoma, ATCC CRL-1555). Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of the mouse anti-SRPK2 antibody.
anti-SFRS Protein Kinase 2 (SRPK2) (AA 363-485) antibody (3) anti-SFRS Protein Kinase 2 (SRPK2) (AA 363-485) antibody (Image 3)
Product cited in: Wang, Lin, Dyck et al.: "SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells." in: The Journal of cell biology, Vol. 140, Issue 4, pp. 737-50, 1998 (PubMed).

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