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Details for Product No. ABIN968433

Integrin beta 4 (ITGB4) (AA 1612-1821) antibody

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Antigen
Synonyms CD104, AA407042, C230078O20
Epitope
»Alternatives AA 1612-1821
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunofluorescence (IF)
Pubmed 2 references available
Catalog no. ABIN968433
Quantity 50 µg
Price
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Immunogen Human Integrin beta4
Clone 7
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Please refer to us for technical protocols.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name CD104
Background Cell adhesion to extracellular matrix components or to cell surface proteins, especially those expressed by leukocytes and endothelial cells, is mediated by integrins. Integrins contain noncovalently associated alpha and beta subunits. At least 17 alpha and 8 beta subunits have been identified and these proteins can heterodimerize to form 22 different receptors. The alpha6beta4 integrin is a receptor for various laminins and binds with the highest affinity to laminins 4 and 5. It exhibits elevated expression in the basal cell layer of stratified epithelia, in Schwann cells at the onset of myelination, and in CD4-CD8- pre-T lymphocytes entering the thymus. In addition, alpha6beta4 expression is increased in squamous carcinomas where it promotes invasion through a targeting of PI3 kinase activity. The majority of beta4 comprises a cytoplasmic domain with unique signaling properties. The C-terminal portion of this domain contains two pairs of type III fibronectin-like motifs (FNIII) and a tyrosine activation motif (TAM). Additional domains in the cytoplasmic tail bind Shc and activate the MAPK pathway. Thus, integrin beta4 is an integrin subunit that is important for cell survival, growth, and differentiation. This antibody is routinely tested by western blot analysis.
Synonyms: Integrin beta4
Molecular Weight 200 kDa
Research Area CD Antigens, Surface Receptors of Immune Cells
Comment

Related Products: ABIN968533, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Mainiero, Pepe, Wary et al.: "Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes." in: The EMBO journal, Vol. 14, Issue 18, pp. 4470-81, 1995 (PubMed).

Shaw, Rabinovitz, Wang et al.: "Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion." in: Cell, Vol. 91, Issue 7, pp. 949-60, 1998 (PubMed).

Alternatives for antigen "Integrin beta 4 (ITGB4)", type "Antibodies"
Hosts (102), (52), (44), (2), (1)
Reactivities (146), (103), (73), (46), (46), (41), (12)
Applications (129), (88), (50), (46), (42), (25), (24), (23), (19), (9), (6), (5), (3), (1), (1)
Conjugates (21), (17), (8), (7), (5), (5), (5), (5), (5), (5), (5), (5), (3), (3), (3), (3), (3)
Epitopes (17), (12), (12), (6), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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