Syntaxin 8 (STX8) (AA 57-164) antibody

Details for Product No. ABIN968489
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Antigen
Synonyms
CG4109, Dm Syx8, DmSyx8, Dmel\\CG4109, SYX8, Syx, zgc:64079, syntaxin-8, STX8, GB11192, MGC116467, DDBDRAFT_0217663, DDBDRAFT_0231533, DDB_0217663, DDB_0231533, CARB, 0610007H08Rik, 1110002H11Rik, 493 ... show more
CG4109, Dm Syx8, DmSyx8, Dmel\\CG4109, SYX8, Syx, zgc:64079, syntaxin-8, STX8, GB11192, MGC116467, DDBDRAFT_0217663, DDBDRAFT_0231533, DDB_0217663, DDB_0231533, CARB, 0610007H08Rik, 1110002H11Rik, 4930571E13Rik show less
Epitope
AA 57-164
(8), (8), (7), (4), (4), (2), (1)
Reactivity
Mouse (Murine)
(21), (13), (4), (1)
Host
Mouse
(19), (10), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB), Immunofluorescence (IF)
(28), (18), (3), (3), (1), (1)
Pubmed 2 references available
Quantity 50 µg
Options
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Catalog No. ABIN968489
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Immunogen Mouse Syntaxin 8
Clone CE6
Isotype IgG2a
Cross-Reactivity Human, Dog (Canine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Syntaxin 8
Background Eukaryotic protein trafficking involves the packaging of molecules into membranous vesicles that bud from a donor compartment, travel to a specific destination, fuse, and release their components into an acceptor compartment. Recognition between vesicle and acceptor membrane is mediated by the pairing of the integral membrane SNARE proteins. The stable interaction between vesicle proteins (v-SNAREs) and target proteins (t-SNAREs) juxtaposes the membranes and results in an activated docking state and/or membrane fusion. The syntaxin protein family contains a number of members that serve as functional t-SNAREs. One member of this family, syntaxin 8, has two coiled-coil domains, one in the N-terminus and one toward the C-terminus. The C-terminal domain is homologous to a similar domain in syntaxin 6 and is predicted to interact in the formation of SNARE complexes, while a hydrophobic domain in the C-terminus may be involved in membrane anchoring. Syntaxin-8 is ubiquitously expressed, but is present at high levels in the heart and localizes specifically to the ER. Thus, syntaxin-8 is a t-SNARE that is thought to be involved in the early secretory pathway of many different cell types.
Molecular Weight 27 kDa
Research Area Signaling, Organelles, Chromatin and Nuclear Signaling, Cytoskeleton, Microfilaments
Comment

Related Products: ABIN967389, ABIN968536

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Syntaxin 8 (STX8) (AA 57-164) antibody Immunofluorescent staining of WI38 cells.
anti-Syntaxin 8 (STX8) (AA 57-164) antibody (2) Western blot analysis of Syntaxin 8 on human cell endothelial lysate. Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of anti-Syntaxin 8.
Product cited in: Steegmaier, Yang, Yoo et al.: "Three novel proteins of the syntaxin/SNAP-25 family." in: The Journal of biological chemistry, Vol. 273, Issue 51, pp. 34171-9, 1999 (PubMed).

Thoreau, Bergès, Callebaut et al.: "Molecular cloning, expression analysis, and chromosomal localization of human syntaxin 8 (STX8)." in: Biochemical and biophysical research communications, Vol. 257, Issue 2, pp. 577-83, 1999 (PubMed).

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