anti-Adiponectin antibody (Adiponectin, C1Q and Collagen Domain Containing) (AA 1-247)

Details for Product anti-ADIPOQ Antibody No. ABIN968621
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Synonyms MGC84292, ADIPOQ, APM1, ACDC, ACRP30, ADIPQTL1, ADPN, APM-1, GBP28, 30kDa, APN, Acdc, Acrp30, adipo, apM1, ADN
AA 1-247
(51), (29), (25), (17), (10), (6), (5), (5), (5), (4), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(489), (141), (91), (19), (12), (4), (3), (2), (2)
(325), (275), (18), (12), (4), (4)
Clonality (Clone)
Monoclonal ()
This Adiponectin antibody is un-conjugated
(63), (22), (18), (4), (1), (1), (1), (1)
Immunofluorescence (IF), Western Blotting (WB)
(438), (399), (84), (60), (49), (39), (19), (14), (13), (13), (11), (10), (8), (4), (4), (4), (2), (1), (1), (1), (1), (1), (1)
Pubmed 2 references available
Quantity 50 μg
Shipping to United States ( )
Immunogen Human Acrp30 aa. 1-247
Clone 31-Acrp30
Isotype IgG2a
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Acrp30 (ADIPOQ Antibody Abstract)
Background Adipocytes express a variety of proteins that function in the homeostatic control of glucose and lipid metabolism. Insulin regulates the translocation and secretion of many of these adipocyte proteins in response to homeostatic changes in energy balance. Both adipsin and adipocyte complement-related protein of 30 kDa (Acrp30) are secretory proteins whose secretion from adipocytes is enhanced by insulin stimulation. Acrp30 contains N-terminal collagen repeats and a globular C-terminal domain. It is homologous to collagen type VIII and X and to complement factor C1q. Also, it forms homo-oligomeric structures of 90 and 300 kDa. The expression of Acrp30 increases 100 fold during adipocyte differentiation and it is commonly found in serum. Insulin stimulation of 3T3-L1 fibroblasts leads to a 4-fold increase in Acrp30 secretion. This secretion is regulated by PI3-kinase activity and may involve a secretory pathway that is distinct from other insulin-regulated secretory pathways, such as that involved with the translocation of glucose transporters and transferrin receptors. Thus, Acrp30 is an adipocyte secretory protein that functions in the regulation of energy homeostasis.
Synonyms: Adiponectin
Molecular Weight 30 kDa
Pathways AMPK Signaling

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-Adiponectin antibody (Adiponectin, C1Q and Collagen Domain Containing) (AA 1-247) (ABIN968621) Western blot analysis of Acrp30 on plasma lysate. Lane 1: 1:500, lane 2: 1:1000, lane...
Product cited in: Bogan, Lodish: "Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4." in: The Journal of cell biology, Vol. 146, Issue 3, pp. 609-20, 1999 (PubMed).

Background publications Scherer, Williams, Fogliano et al.: "A novel serum protein similar to C1q, produced exclusively in adipocytes." in: The Journal of biological chemistry, Vol. 270, Issue 45, pp. 26746-9, 1995 (PubMed).

Catalog No. ABIN968621
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