C-terminal Binding Protein 2 (CTBP2) (AA 361-445) antibody

Details for Product No. ABIN968723
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

 
Antigen
Synonyms Ribeye, Gtrgeo6, AA407280, D7Ertd45e, fe05b01, wu:fb96g03, wu:fe05b01, wu:fk19e02, ctbp, ctbp-b, xctbp
Epitope
AA 361-445
(19), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine)
(46), (28), (27), (14), (12), (12), (2), (2), (2)
Host
Mouse
(47), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF)
(37), (16), (13), (9), (9), (6), (4), (3), (2)
Pubmed 6 references available
Catalog no. ABIN968723
Quantity 50 µg
Price
Contact our Customer Service for availability and price in your country.
Options
Shipping to United States (Change)
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Mouse CtBP2
Clone Ghr6
Isotype IgG1
Cross-Reactivity Rat (Rattus), Human, Dog (Canine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name CtBP2
Background Transcriptional repression is critical for genetic regulation of many cellular proteins, and involves either a transcription regulator that has an intrinsic repressor domain, or a transcription regulator that contains a binding site in the regulatory domain where a co-repressor can bind. C-terminal binding proteins (CtBP1 and CtBP2) are a class of co-repressors that interact with a subset of transcription factors through a PLDLSL sequence motif. CtBP1 and CtBP2 are 80% homologous, and both are expressed at high levels in embryonic tissues. However, CtBP1 is expressed higher in adult tissues, and is more widely expressed in embryonic and adult tissues. Both CtBP1 and CtBP2 bind the deltaEF1 zinc finger-homeodomain transcription factor, and enhance transcriptional repression via interaction with the PLDLSL-sequence in deltaEF1. CtBP1 and CtBP2 bind other zinc finger transcription factors, including Kheper and BKLF. In addition, CtBP2 interacts with other transcription factors, such as hFOG-2, Evi-1, AREB6, and ZEB. Thus, CtBP1 and CtBP2 may be important co-repressors for a variety of transcriptional factors. This antibody is routinely tested by western blot analysis.
Synonyms: C-Terminal Binding Protein-2
Molecular Weight 48 kDa
Comment

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Supplier Images
anti-C-terminal Binding Protein 2 (CTBP2) (AA 361-445) antibody Western blot analysis of CtBP2 on a BC3H1 cell lysate (Mouse brain smooth muscle-like cells, ATCC CRL-1443). Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of the mouse anti-CtBP2 antibody.
anti-C-terminal Binding Protein 2 (CTBP2) (AA 361-445) antibody (2) Immunofluorescence staining of SK-N-MC (Human neuroblastoma, ATCC HTB-10).
Product cited in: Katsanis, Fisher: "A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3." in: Genomics, Vol. 47, Issue 2, pp. 294-9, 1998 (PubMed).

Turner, Crossley: "Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators." in: The EMBO journal, Vol. 17, Issue 17, pp. 5129-40, 1998 (PubMed).

Furusawa, Moribe, Kondoh et al.: "Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor deltaEF1." in: Molecular and cellular biology, Vol. 19, Issue 12, pp. 8581-90, 2000 (PubMed).

Muraoka, Ichikawa, Shi et al.: "Kheper, a novel ZFH/deltaEF1 family member, regulates the development of the neuroectoderm of zebrafish (Danio rerio)." in: Developmental biology, Vol. 228, Issue 1, pp. 29-40, 2001 (PubMed).

Hildebrand, Soriano: "Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse development." in: Molecular and cellular biology, Vol. 22, Issue 15, pp. 5296-307, 2002 (PubMed).

Hendrickson, Troilo, Djajadi et al.: "Expression of synaptic and phototransduction markers during photoreceptor development in the marmoset monkey Callithrix jacchus." in: The Journal of comparative neurology, Vol. 512, Issue 2, pp. 218-31, 2008 (PubMed).

Hosts (47), (4)
Reactivities (46), (28), (27), (14), (12), (12), (2), (2), (2)
Applications (37), (16), (13), (9), (9), (6), (4), (3), (2)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (19), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
back to top