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C-Src tyrosine Kinase (CSK) antibody

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Synonyms AW212630
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Human, Mouse (Murine), Monkey, Rat (Rattus)
(166), (70), (60), (6), (6), (5), (3), (1), (1), (1), (1)
(124), (26), (23)
Clonality (Clone)
Monoclonal ()
(7), (7), (7), (5), (5), (5), (2), (2), (2), (2), (2), (2), (2), (2)
Flow Cytometry (FACS), Immunocytochemistry (ICC), ELISA, Western Blotting (WB)
(151), (72), (32), (22), (20), (19), (16), (11), (5), (3), (2), (1), (1)
Pubmed 3 references available
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Quantity 100 μL
Shipping to United States ( )
Availability Will be delivered in 3 to 4 Business Days
Immunogen Purified recombinant fragment of human CSK expressed in E. coli.
Clone 5F3
Isotype IgG1
Purification Ascites
Alternative Name CSK (CSK Antibody Abstract)
Background Carboxy-terminal Src kinase (Csk) is a ubiquitously expressed nonreceptor tyrosine kinase that negatively regulates the Src family kinases (SFK) by phosphorylation of the SFK carboxy-terminal tyrosine. Phosphorylated carboxy-terminal tyrosine binds to the SH2 domain of SFK intramolecularly and leads to folding and inactivation of the SFK . This Csk-catalyzed SFK tyrosine phosphorylation is highly specific and exclusive. The SFK carboxy-terminal tyrosine is the only known physiological substrate of Csk .Tissue specificity: Expressed in lung and macrophages.
Molecular Weight 50 kDa
Gene ID 1445
HGNC 1445
Research Area Signaling, Tyrosine Kinases
Pathways EGFR Signaling Pathway
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
Flow Cytometry (FACS) image for anti-C-Src tyrosine Kinase (CSK) antibody (ABIN969069) Figure 1: Flow cytometric analysis of HL-60 cells using CSK mouse mAb (green) and neg...
Immunocytochemistry (ICC) image for anti-C-Src tyrosine Kinase (CSK) antibody (ABIN969069) Figure 2: Immunofluorescence analysis of U251 cells using CSK mouse mAb (green) . Blu...
Western Blotting (WB) image for anti-C-Src tyrosine Kinase (CSK) antibody (ABIN969069) Figure 3: Western blot analysis using CSK mouse mAb against NIH/3T3 (1) ,Hela (2) ,CO...
Product cited in: Ho, Levy, Rose et al.: "Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health Study." in: Journal of hypertension, Vol. 29, Issue 1, pp. 62-9, 2010 (PubMed).

Kreil, Hochhaus, Cross et al.: "A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias." in: Leukemia research, Vol. 33, Issue 9, pp. e168-9, 2009 (PubMed).

Levy, Ehret, Rice et al.: "Genome-wide association study of blood pressure and hypertension. ..." in: Nature genetics, Vol. 41, Issue 6, pp. 677-87, 2010 (PubMed).

Catalog No. ABIN969069
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