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Details for Product No. ABIN969069

C-Src tyrosine Kinase (CSK) antibody

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Antigen
Synonyms AW212630
Reactivity
»Alternatives Human, Mouse (Murine), Monkey, Rat (Rattus)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB), Immunocytochemistry (ICC), Fluorescence Microscopy (FM)
Pubmed 2 references available
Catalog no. ABIN969069
Quantity 100 µL
Price
363.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 3 to 4 Business Days
Immunogen Purified recombinant fragment of human CSK expressed in E. coli.
Clone 5F3
Isotype IgG1
Purification Ascites
Alternative Name CSK
Background Synonyms:
MGC117393, CSK
Carboxy-terminal Src kinase (Csk) is a ubiquitously expressed nonreceptor tyrosine kinase that negatively regulates the Src family kinases (SFK) by phosphorylation of the SFK carboxy-terminal tyrosine. Phosphorylated carboxy-terminal tyrosine binds to the SH2 domain of SFK intramolecularly and leads to folding and inactivation of the SFK. This Csk-catalyzed SFK tyrosine phosphorylation is highly specific and exclusive. The SFK carboxy-terminal tyrosine is the only known physiological substrate of Csk. Tissue specificity: Expressed in lung and macrophages.
Molecular Weight 50 kDa
Gene ID 1445
Research Area Signaling, Tyrosine Kinases
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Product cited in: Levy, Ehret, Rice et al.: "Genome-wide association study of blood pressure and hypertension." in: Nature genetics, Vol. 41, Issue 6, pp. 677-87, 2010 (PubMed).

Kreil, Hochhaus, Cross et al.: "A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias." in: Leukemia research, Vol. 33, Issue 9, pp. e168-9, 2009 (PubMed).

Alternatives for antigen "C-Src tyrosine Kinase (CSK)", type "Antibodies"
Hosts (72), (20), (11)
Reactivities (96), (60), (53), (28), (24), (24), (14), (3)
Applications (80), (37), (20), (16), (14), (14), (10), (8), (2), (2), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (17), (15), (7), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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