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C-Src tyrosine Kinase (CSK) antibody

Antigen

C-Src tyrosine Kinase (CSK)
Synonyms MGC117393, AW212630, MGC112926
Clonality Monoclonal (5F3)
Host
Alternatives

Mouse
Reactivity
Alternatives

Human, Mouse (Murine), Monkey, Rat (Rattus)
Application
Alternatives ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Western Blotting (WB)
2 references available
Catalog no. ABIN969069
Quantity 0.1ml
Price 363.00 $   Plus shipping costs $45.00
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Additional Information
Application Details Publications Alternatives back to top

Alternative name CSK
Gene ID 1445
Immunogen Purified recombinant fragment of human CSK expressed in E. Coli.
Format Liquid
Isotype IgG1
Clone 5F3
Description Carboxy-terminal Src kinase (Csk) is a ubiquitously expressed nonreceptor tyrosine kinase that negatively regulates the Src family kinases (SFK) by phosphorylation of the SFK carboxy-terminal tyrosine. Phosphorylated carboxy-terminal tyrosine binds to the SH2 domain of SFK intramolecularly and leads to folding and inactivation of the SFK . This Csk-catalyzed SFK tyrosine phosphorylation is highly specific and exclusive. The SFK carboxy-terminal tyrosine is the only known physiological substrate of Csk .Tissue specificity: Expressed in lung and macrophages.
Synonyms: MGC117393, CSK
Molecular Weight 50kDa

Application Details
Publications Alternatives back to top

Application Notes Western Blotting: 1/500 - 1/2000.
Immunofluorescence: 1/200 - 1/1000.
Flow cytometry: 1/200 - 1/400.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Purification Ascites
Buffer Ascitic fluid containing 0.03% sodium azide.
Preservative 0.03% sodium azide
Storage Store at 4℃, for long term storage, store at -20℃.
Research Area Signaling, Tyrosine Kinases
Restrictions For Research Use only

Publications
Application Details Alternatives back to top

Product Levy, Ehret, Rice et al.: "Genome-wide association study of blood pressure and hypertension." in: Nature genetics, Vol. 41, Issue 6, pp. 677-87, 2010 (PubMed).

Kreil, Hochhaus, Cross et al.: "A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias." in: Leukemia research, Vol. 33, Issue 9, pp. e168-9, 2009 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "C-Src tyrosine Kinase (CSK)", type "Antibodies"
Hosts Rabbit (27), Mouse (10), Goat (8)
Reactivities Human (39), Rat (Rattus) (13), Mouse (Murine) (12), Cow (Bovine) (3), Monkey (2), Cat (Feline) (1), Chicken (1), Dog (Canine) (1)
Applications Western Blotting (WB) (44), ELISA (21), Immunohistochemistry (IHC) (9), Immunoprecipitation (IP) (9), Immunofluorescence (IF) (7), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (7), Immunocytochemistry (ICC) (4), Flow Cytometry (FACS) (2)
Epitopes C-Term (9), AA 330-450 (3), N-Term (2), C-Term,AA 330-450 (1), Internal Region (1), Middle Region (1), Val399 (1), pSer364 (1)