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CSK antibody

CSK Reactivity: Human WB, IHC Host: Rabbit Monoclonal unconjugated
Catalog No. ABIN7101334
  • Target See all CSK Antibodies
    CSK (C-Src tyrosine Kinase (CSK))
    Reactivity
    • 111
    • 57
    • 45
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 99
    • 11
    • 3
    Rabbit
    Clonality
    • 100
    • 12
    Monoclonal
    Conjugate
    • 53
    • 9
    • 7
    • 7
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    This CSK antibody is un-conjugated
    Application
    • 101
    • 49
    • 26
    • 26
    • 16
    • 15
    • 12
    • 9
    • 7
    • 7
    • 6
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Monoclonal Antibodies
    Purification
    Affinity purification
    Immunogen
    A synthesized peptide derived from human CSK
    Isotype
    IgG
    Top Product
    Discover our top product CSK Primary Antibody
  • Application Notes
    WB,1:500 - 1:2000,IHC,1:50 - 1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid freeze / thaw cycles
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    CSK (C-Src tyrosine Kinase (CSK))
    Alternative Name
    CSK (CSK Products)
    Synonyms
    AW212630 antibody, C-terminal Src kinase antibody, c-src tyrosine kinase antibody, CSK, non-receptor tyrosine kinase antibody, CSK antibody, Csk antibody
    Background
    Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR and B-cell receptor (BCR by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.,CSK, tyrosine-protein kinase CSK,B Cell Receptor Signaling Pathway,Immunology & Inflammation,Kinase,Kinase_Tyrosine kinases,Signal Transduction,CSK
    Molecular Weight
    50 kDa
    Gene ID
    1445
    UniProt
    P41240
    Pathways
    TCR Signaling, EGFR Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events
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