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GATA Binding Protein 4 (GATA4) antibody

Details for Product No. ABIN969169, Supplier: Login to see
Antigen
  • gata-4
  • xgata4
  • xGATA-4
  • MGC81427
  • GATA4
  • GATA-4
  • Gata4
  • gata4
  • ASD2
  • VSD1
  • Gata-4
  • gata
Reactivity
Human, Mouse (Murine)
155
85
80
6
5
2
2
1
Host
Mouse
133
27
3
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
3
3
3
2
2
2
2
2
2
2
2
2
1
Application
ELISA, Western Blotting (WB)
118
58
39
24
19
18
14
6
2
2
2
1
1
1
Supplier
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Immunogen Purified recombinant fragment of human GATA4 expressed in E. coli.
Clone 6H10
Isotype IgG2b
Purification Ascites
Alternative Name GATA4 (GATA4 Antibody Abstract)
Background GATA binding protein 4, also known as GATA4, it is a 46 kDa member of the GATA family of zinc-finger transcription factors. Members of this family is involved in the development of cardiac hypertrophy and remodeling, and plays a critical role in regulating basal and agonist or stress induced gene expression in cardiac and smooth muscle cell types. These factors recognize the GATA motif which is present in the promoters of many genes. GATA4 contains a conserved MAPK phosphorylation site at serine 105 within the transcriptional activation domain. Serine 105 of GATA4 is phosphorylated in response to agonist stimulation through MEK 1 ERK1 / 2, and weakly through JNK or p38 MAPKs. GATA4 is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects.
Molecular Weight 46 kDa
Gene ID 2626
HGNC 2626
Research Area Hypertrophy, Lineage Markers, Transcription Factors
Pathways
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
Western Blotting (WB) image for anti-GATA Binding Protein 4 (GATA4) antibody (ABIN969169) Figure 1: Western blot analysis using GATA4 mouse mAb against rat fetal heart (1) and...
Product cited in: Rajagopal, Ma, Obler et al.: "Spectrum of heart disease associated with murine and human GATA4 mutation." in: Journal of molecular and cellular cardiology, Vol. 43, Issue 6, pp. 677-85, 2007 (PubMed).

Belaguli, Sepulveda, Nigam et al.: "Cardiac tissue enriched factors serum response factor and GATA-4 are mutual coregulators." in: Molecular and cellular biology, Vol. 20, Issue 20, pp. 7550-8, 2000 (PubMed).

Background publications Durocher, Charron, Warren et al.: "The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors." in: The EMBO journal, Vol. 16, Issue 18, pp. 5687-96, 1997 (PubMed).