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Lysyl-tRNA Synthetase (KARS) (AA 90-174) antibody

Details for Product No. ABIN969226, Supplier: Log in to see
Antigen
  • CG12141
  • Dmel\\CG12141
  • KRS
  • LysRS
  • cb530
  • wu:fa16h02
  • zgc:92483
  • kars
  • MGC53345
  • kars2
  • krs
  • krs-1
  • KARS
  • Tb06.28P18.190
  • CMTRIB
  • DFNB89
  • KARS1
  • KARS2
  • AA589550
  • AL024334
  • AL033315
  • AL033367
  • D8Ertd698e
  • D8Wsu108e
  • mKIAA0070
Epitope
AA 90-174
6
6
4
4
1
1
1
Reactivity
Human
48
23
19
1
Host
Mouse
39
10
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
35
17
17
12
11
5
4
4
3
1
1
Supplier
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Immunogen Purified recombinant fragment of KARS (AA 90-174) expressed in E. coli.
Clone 8G12C1
Isotype IgG1
Purification Ascites
Alternative Name KARS (KARS Antibody Abstract)
Background KARS: lysyl-tRNA synthetase. Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis.
Gene ID 3735
HGNC 3735
Pathways
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
Immunohistochemistry (IHC) image for anti-Lysyl-tRNA Synthetase (KARS) (AA 90-174) antibody (ABIN969226) Figure 1: Immunohistochemical analysis of paraffin-embedded human cervical carcinoma,...
Immunohistochemistry (IHC) image for anti-Lysyl-tRNA Synthetase (KARS) (AA 90-174) antibody (ABIN969226) Figure 2: Immunohistochemical analysis of paraffin-embedded human Tonsil tissues usin...
Western Blotting (WB) image for anti-Lysyl-tRNA Synthetase (KARS) (AA 90-174) antibody (ABIN969226) Figure 3: Western blot analysis using KARS mouse mAb against truncated Trx-KARS recom...
Product cited in: Sampath, Mazumder, Seshadri et al.: "Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation." in: Cell, Vol. 119, Issue 2, pp. 195-208, 2004 (PubMed).

Sang Lee, Gyu Park, Park et al.: "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex." in: Biochemical and biophysical research communications, Vol. 291, Issue 1, pp. 158-64, 2002 (PubMed).

Cen, Khorchid, Javanbakht et al.: "Incorporation of lysyl-tRNA synthetase into human immunodeficiency virus type 1." in: Journal of virology, Vol. 75, Issue 11, pp. 5043-8, 2001 (PubMed).

Tolkunova, Park, Xia et al.: "The human lysyl-tRNA synthetase gene encodes both the cytoplasmic and mitochondrial enzymes by means of an unusual alternative splicing of the primary transcript." in: The Journal of biological chemistry, Vol. 275, Issue 45, pp. 35063-9, 2000 (PubMed).