Lysyl-tRNA Synthetase (KARS) (AA 90-174) antibody

Details for Product No. ABIN969226
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Antigen
Synonyms
CG12141, Dmel\\CG12141, KRS, LysRS, cb530, wu:fa16h02, zgc:92483, kars, MGC53345, kars2, krs, krs-1, KARS, Tb06.28P18.190, CMTRIB, DFNB89, KARS1, KARS2, AA589550, AL024334, AL033315, AL033367, D8Ertd6 ... show more
CG12141, Dmel\\CG12141, KRS, LysRS, cb530, wu:fa16h02, zgc:92483, kars, MGC53345, kars2, krs, krs-1, KARS, Tb06.28P18.190, CMTRIB, DFNB89, KARS1, KARS2, AA589550, AL024334, AL033315, AL033367, D8Ertd698e, D8Wsu108e, mKIAA0070 show less
Epitope
AA 90-174
(5), (4), (2), (2), (1), (1)
Reactivity
Human
(33), (18), (14), (13), (12), (12), (12)
Host
Mouse
(28), (8)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(26), (11), (11), (10), (9), (3), (3), (2), (2)
Pubmed 4 references available
Quantity 100 µL
Options
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Catalog No. ABIN969226
363.00 $
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Immunogen Purified recombinant fragment of KARS (AA 90-174) expressed in E. coli.
Clone 8G12C1
Isotype IgG1
Purification Ascites
Alternative Name KARS
Background Synonyms:
KRS, KARS2, KIAA0070
KARS: lysyl-tRNA synthηse. Aminoacyl-tRNA synthηses are a class of enzymes that charge tRNAs with their cognate AA. Lysyl-tRNA synthηse is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthηses. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis.
Gene ID 3735
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-Lysyl-tRNA Synthetase (KARS) (AA 90-174) antibody Figure 2: Immunohistochemical analysis of paraffin-embedded human cervical carcinoma, showing cytoplasmic localization with DAB staining using KARS mouse mAb.
anti-Lysyl-tRNA Synthetase (KARS) (AA 90-174) antibody (2) Figure 3: Immunohistochemical analysis of paraffin-embedded human Tonsil tissues using KARS mouse mAb
anti-Lysyl-tRNA Synthetase (KARS) (AA 90-174) antibody (3) Figure 1: Western blot analysis using KARS mouse mAb against truncated Trx-KARS recombinant protein (1), truncated MBP-KARS (aa90-174) and full length KARS (aa1-188) transfected CHO-K1 cell lysate (3) .
Product cited in: Tolkunova, Park, Xia et al.: "The human lysyl-tRNA synthetase gene encodes both the cytoplasmic and mitochondrial enzymes by means of an unusual alternative splicing of the primary transcript." in: The Journal of biological chemistry, Vol. 275, Issue 45, pp. 35063-9, 2000 (PubMed).

Cen, Khorchid, Javanbakht et al.: "Incorporation of lysyl-tRNA synthetase into human immunodeficiency virus type 1." in: Journal of virology, Vol. 75, Issue 11, pp. 5043-8, 2001 (PubMed).

Sang Lee, Gyu Park, Park et al.: "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex." in: Biochemical and biophysical research communications, Vol. 291, Issue 1, pp. 158-64, 2002 (PubMed).

Sampath, Mazumder, Seshadri et al.: "Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation." in: Cell, Vol. 119, Issue 2, pp. 195-208, 2004 (PubMed).

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