Lysine (K)-Specific Demethylase 3A (KDM3A) antibody

Details for Product No. ABIN969228
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Antigen
Synonyms tsga, jmjd1, jhdm2a, jhmd2a, jmjd1a, KDM3A, JMJD1A, kdm3a, JHDM2A, JHMD2A, JMJD1, TSGA, 1700105C21Rik, C230043E16Rik, JHDM2a, Jmjd1, Jmjd1a, KDM2A, TGSA, Tsga, mKIAA0742
Reactivity
Human
(71), (20), (12), (2), (1), (1), (1), (1)
Host
Mouse
(52), (19)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(67), (39), (38), (18), (11), (10), (4), (4), (3), (1)
Pubmed 3 references available
Quantity 100 μL
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Immunogen Purified recombinant fragment of human KDM3A expressed in E. coli.
Clone 1-00E-12
Isotype IgG1
Purification Ascites
Alternative Name KDM3A (KDM3A Antibody Abstract)
Background Synonyms:
TSGA, JMJD1, JHDM2A, JHMD2A, JMJD1A, KIAA0742, DKFZp686A24246, DKFZp686P07111, kDaM3A
This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. JMJD1A functions as a mono- and dimethylation-specific demethylase, binding iron and α-ketoglutarate as cofactors and demethylating Lysine 9 of Histone H3. This suggests that JMJD1A plays a central role in the histone code and participates in nuclear hormone receptor-based transcriptional regulation. In addition, JMJD1A plays an important role in the regulation of cell growth during development and in chromatin regulation. JMJD1A directly regulates the expression of TNP1 and Protamine 1 (proteins required for the proper packaging and condensation of sperm chromatin) and, therefore, plays an essential role in spermatogenesis.
Molecular Weight 147 kDa
Gene ID 55818
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-Lysine (K)-Specific Demethylase 3A (KDM3A) antibody Figure 2: Immunohistochemical analysis of paraffin-embedded colonic cancer tissues (l...
anti-Lysine (K)-Specific Demethylase 3A (KDM3A) antibody (2) Figure 1: Western blot analysis using KDM3A mouse mAb against Hela (1) and HepG2 (2) ...
Product cited in: Hillier, Graves, Fulton et al.: "Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ..." in: Nature, Vol. 434, Issue 7034, pp. 724-31, 2005 (PubMed).

Beausoleil, Jedrychowski, Schwartz et al.: "Large-scale characterization of HeLa cell nuclear phosphoproteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 33, pp. 12130-5, 2004 (PubMed).

Nagase, Ishikawa, Suyama et al.: "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 5, Issue 5, pp. 277-86, 1999 (PubMed).

Validation Images
Catalog No. ABIN969228
393.80 $
Plus shipping costs $45.00
Quantity
Price
100 μL
393.80 $

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