KLHL1 antibody

Catalog No. ABIN969241

This Mouse Monoclonal antibody specifically detects KLHL1 in ELISA and ICC. It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for KLHL1 antibody (ABIN969241)

Target: KLHL1 (Kelch-Like 1 (KLHL1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This KLHL1 antibody is un-conjugated

Application: ELISA, Immunocytochemistry (ICC)

Clone: 3A8

Product Details anti-KLHL1 Antibody

Purpose: KLHL1 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human KLHL1 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-KLHL1 antibody (ABIN969241)

Barrios-Rodiles, Brown, Ozdamar, Bose, Liu, Donovan, Shinjo, Liu, Dembowy, Taylor, Luga, Przulj, Robinson, Suzuki, Hayashizaki, Jurisica, Wrana: "High-throughput mapping of a dynamic signaling network in mammalian cells." in: Science (New York, N.Y.), Vol. 307, Issue 5715, pp. 1621-5, (2005) (PubMed).

Target Details for KLHL1

Target: KLHL1 (Kelch-Like 1 (KLHL1))

Alternative Name: KLHL1

Background: The mammalian Kelch like 1 (KLHL1) was initially discovered as a homolog to the Drosophila Kelch gene that is highly expressed in several brain tissues. The predicted protein domain structure of KLHL1 is characteristic of a number of proteins that bind actin, form dimers, and often act as actin organizing proteins. Based on the presence of anti sense RNA that spans the transcription and translation start sites as well as the first splice site of KLHL1 in brain tissue of individuals suffering from the neurodegenerative disorder spinocerebellar ataxia type 8 (SCA8), it has been suggested that KLHL1 is involved in this disease and that regulation of KLHL1 protein may be affected by antisense RNA expression.Tissue specificity: Highly expressed in brain.

Molecular Weight: 82 kDa

Gene ID: 57626

UniProt: Q9NR64